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Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes

Author

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  • Xiao-Yan Zhu

    (University of Science and Technology of China)

  • Wenyu Gao

    (Changchun University of Technology)

  • Jian-Lin Xu

    (University of Science and Technology of China)

  • Zi-Lu Wang

    (University of Science and Technology of China)

  • Jin-Bo Zhao

    (Changchun University of Technology)

  • Yun-He Xu

    (University of Science and Technology of China)

Abstract

This study presents a copper-catalyzed, substrate-controlled regio- and enantioselective intermolecular hydrosilylation method capable of accommodating a broad scope of alkenes and prochiral silanes. The approach offers an efficient and versatile pathway to generate enantioenriched linear and branched alkyl-substituted Si-stereogenic silanes. Key features of this reaction include mild reaction conditions, simple catalytic systems, compatibility with diverse substrates, high yields and enantioselectivities.

Suggested Citation

  • Xiao-Yan Zhu & Wenyu Gao & Jian-Lin Xu & Zi-Lu Wang & Jin-Bo Zhao & Yun-He Xu, 2025. "Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-55592-1
    DOI: 10.1038/s41467-024-55592-1
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    References listed on IDEAS

    as
    1. Zi-Lu Wang & Qi Li & Meng-Wei Yang & Zhao-Xin Song & Zhen-Yu Xiao & Wei-Wei Ma & Jin-Bo Zhao & Yun-He Xu, 2023. "Regio- and enantioselective CuH-catalyzed 1,2- and 1,4-hydrosilylation of 1,3-enynes," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Xing-Wei Gu & Yu-Li Sun & Jia-Le Xie & Xing-Ben Wang & Zheng Xu & Guan-Wu Yin & Li Li & Ke-Fang Yang & Li-Wen Xu, 2020. "Stereospecific Si-C coupling and remote control of axial chirality by enantioselective palladium-catalyzed hydrosilylation of maleimides," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    3. Tianbao Hu & Chen Zhao & Yan Zhang & Yuzhong Kuang & Lu Gao & Wanshu Wang & Zhishan Su & Zhenlei Song, 2023. "Enantioconvergent construction of stereogenic silicon via Lewis base-catalyzed dynamic kinetic silyletherification of racemic chlorosilanes," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
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