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Living plastics from plasticizer-assisted thermal molding of silk protein

Author

Listed:
  • Yushu Wang

    (Tufts University)

  • Junqi Wu

    (Tufts University)

  • Emily J. Hartzell

    (Tufts University)

  • Weiguo Hu

    (University of Massachusetts)

  • Reddhy Mahle

    (Tufts University)

  • Xinxin Li

    (Tufts University)

  • Ying Chen

    (Tufts University)

  • Jugal Kishore Sahoo

    (Tufts University)

  • Cameron Chan

    (Northeastern University)

  • Brooke N. Longo

    (Tufts University)

  • Charlotte S. Jacobus

    (Tufts University)

  • Chunmei Li

    (Tufts University)

  • David L. Kaplan

    (Tufts University)

Abstract

The pursuit of materials, particularly plastics, with a minimal ecological footprint throughout their circular lifecycle, is crucial for advancing sustainable materials development. Living materials composed of embedded yet active organisms can leverage endogenous biotic resources to achieve functional materials that align with sustainability goals. However, current living material systems face challenges such as weak mechanical properties, limited environmental adaptability, and restricted cellular functionality. In this study, we propose an approach to sustainable living materials by incorporating active organisms into silk-based plastics through a plasticizer-assisted thermal molding process. We investigate the mechanism of structure formation in these materials, correlating manufacturing performance to the resulting secondary structure. These silk-based plastics provide a protective matrix for probiotics, ensuring their survival through the harsh gastrointestinal tract and enhancing intestinal delivery. Similarly, soil rhizobacteria encapsulated within the plastics exhibit long-term protease activity, accelerating plastic degradation upon soil exposure. This work demonstrates the potential of sustainable plastics as a form of living materials, where active organisms are processed, entrapped, retain metabolic functions, and are protected in harsh environments.

Suggested Citation

  • Yushu Wang & Junqi Wu & Emily J. Hartzell & Weiguo Hu & Reddhy Mahle & Xinxin Li & Ying Chen & Jugal Kishore Sahoo & Cameron Chan & Brooke N. Longo & Charlotte S. Jacobus & Chunmei Li & David L. Kapla, 2025. "Living plastics from plasticizer-assisted thermal molding of silk protein," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-55097-x
    DOI: 10.1038/s41467-024-55097-x
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    References listed on IDEAS

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    1. Han Sol Kim & Myung Hyun Noh & Evan M. White & Michael V. Kandefer & Austin F. Wright & Debika Datta & Hyun Gyu Lim & Ethan Smiggs & Jason J. Locklin & Md Arifur Rahman & Adam M. Feist & Jonathan K. P, 2024. "Biocomposite thermoplastic polyurethanes containing evolved bacterial spores as living fillers to facilitate polymer disintegration," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Claire M. Fraser & Jonathan A. Eisen & Steven L. Salzberg, 2000. "Microbial genome sequencing," Nature, Nature, vol. 406(6797), pages 799-803, August.
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    4. Christopher DelRe & Yufeng Jiang & Philjun Kang & Junpyo Kwon & Aaron Hall & Ivan Jayapurna & Zhiyuan Ruan & Le Ma & Kyle Zolkin & Tim Li & Corinne D. Scown & Robert O. Ritchie & Thomas P. Russell & T, 2021. "Near-complete depolymerization of polyesters with nano-dispersed enzymes," Nature, Nature, vol. 592(7855), pages 558-563, April.
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