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A reagent to access methyl sulfones

Author

Listed:
  • Yaroslav Poplavskyi

    (Enamine Ltd)

  • Vasyl Ripenko

    (Enamine Ltd
    Taras Shevchenko National University of Kyiv)

  • Sergei Bova

    (Enamine Ltd)

  • Angelina Biitseva

    (Enamine Ltd)

  • Yurii V. Dmitriv

    (Enamine Ltd
    National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”)

  • Andrei A. Tolmachev

    (Enamine Ltd)

  • Iryna V. Sadkova

    (Enamine Ltd)

  • Iryna Pishel

    (Bienta)

  • Oleksii Grygorov

    (Bienta)

  • Vo Quang Huy Phan

    (The University of Texas at Arlington)

  • H. V. Rasika Dias

    (The University of Texas at Arlington)

  • Pavel K. Mykhailiuk

    (Enamine Ltd
    Taras Shevchenko National University of Kyiv)

Abstract

A chemical reagent to access methyl sulfones has been developed. Its reaction with various bis-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF2-, CF3- and even bicyclo[1.1.1]pentane-containing derivatives. These compounds have been demonstrated to have a high potential for use in medicinal chemistry and coordination chemistry.

Suggested Citation

  • Yaroslav Poplavskyi & Vasyl Ripenko & Sergei Bova & Angelina Biitseva & Yurii V. Dmitriv & Andrei A. Tolmachev & Iryna V. Sadkova & Iryna Pishel & Oleksii Grygorov & Vo Quang Huy Phan & H. V. Rasika D, 2025. "A reagent to access methyl sulfones," Nature Communications, Nature, vol. 16(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-55027-x
    DOI: 10.1038/s41467-024-55027-x
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