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Regulation of lanthanide supramolecular nanoreactors via a bimetallic cluster cutting strategy to boost aza-Darzens reactions

Author

Listed:
  • Jingzhe Li

    (Lanzhou University)

  • Manchang Kou

    (Lanzhou University)

  • Shengbin Zhou

    (Lanzhou University)

  • Fan Dong

    (Lanzhou University)

  • Xiaoyu Huang

    (Lanzhou University)

  • Xiaoliang Tang

    (Lanzhou University
    Qinghai Normal University)

  • Yu Tang

    (Lanzhou University)

  • Weisheng Liu

    (Lanzhou University
    Qinghai Normal University)

Abstract

Supramolecular nanoreactor as artificial mimetic enzyme is attracting a growing interest due to fine-tuned cavity and host-guest molecular recognition. Here, we design three 3d-4f metallo-supramolecular nanocages with different cavity sizes and active sites (Zn2Er4L14, Zn4Er6L26, and Zn2Er8L38) based on a “bimetallic cluster cutting” strategy. Three nanocages exhibit a differential catalysis for the three-component aza-Darzens reaction without another additive, and only Zn2Er8L38 with the largest cavity and the most lanthanides centers has excellent catalytic conversion for monosubstituted and disubstituted N-aryl aziridine products. The host-guest relationship investigations confirm that Zn2Er8L38 significantly outperforms Zn2Er4L14 with the smaller cavity and Zn4Er6L26 with the fewer Lewis acidic sites in multi-component reaction is mainly attributed to the synergy of inherent confinement effect and multiple Lewis acidic sites in nanocage. The “bimetallic cluster cutting” strategy for the construction of 3d−4f nanocages with large windows may represent a potential approach to develop supramolecular nanoreactor with high catalytic efficiency.

Suggested Citation

  • Jingzhe Li & Manchang Kou & Shengbin Zhou & Fan Dong & Xiaoyu Huang & Xiaoliang Tang & Yu Tang & Weisheng Liu, 2025. "Regulation of lanthanide supramolecular nanoreactors via a bimetallic cluster cutting strategy to boost aza-Darzens reactions," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-54950-3
    DOI: 10.1038/s41467-024-54950-3
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