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Functional tissue units in the Human Reference Atlas

Author

Listed:
  • Supriya Bidanta

    (Indiana University)

  • Katy Börner

    (Indiana University)

  • Bruce W. Herr II

    (Indiana University)

  • Ellen M. Quardokus

    (Indiana University)

  • Marcell Nagy

    (Budapest University of Technology and Economics
    Semmelweis University)

  • Katherine S. Gustilo

    (Indiana University)

  • Rachel Bajema

    (Indiana University)

  • Elizabeth Maier

    (Indiana University)

  • Roland Molontay

    (Budapest University of Technology and Economics
    Semmelweis University)

  • Griffin M. Weber

    (Harvard Medical School)

Abstract

Functional tissue units form the basic building blocks of organs and are important for understanding and modeling the healthy physiological function of the organ and changes that occur during disease states. In this comprehensive catalog of 22 anatomically based, nested functional tissue units from 10 healthy human organs, we document the definition, physical dimensions, blood vasculature connections, and cellular composition. All anatomy terms are mapped to the multi-species Uber-anatomy Ontology (Uberon) and cells are mapped to Cell Ontology to support computational access via standardized metadata. The catalog includes datasets, illustrations, and a large printable poster illustrating how the blood vasculature connects the 22 functional tissue units in 10 organs. All data and code are freely available. The work is part of an ongoing international effort to construct a Human Reference Atlas of the 37 trillion cells that make up the healthy human body.

Suggested Citation

  • Supriya Bidanta & Katy Börner & Bruce W. Herr II & Ellen M. Quardokus & Marcell Nagy & Katherine S. Gustilo & Rachel Bajema & Elizabeth Maier & Roland Molontay & Griffin M. Weber, 2025. "Functional tissue units in the Human Reference Atlas," Nature Communications, Nature, vol. 16(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-54591-6
    DOI: 10.1038/s41467-024-54591-6
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    References listed on IDEAS

    as
    1. Yashvardhan Jain & Leah L. Godwin & Sripad Joshi & Shriya Mandarapu & Trang Le & Cecilia Lindskog & Emma Lundberg & Katy Börner, 2023. "Segmenting functional tissue units across human organs using community-driven development of generalizable machine learning algorithms," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
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