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In vivo imaging of glycogen in human muscle

Author

Listed:
  • Chongxue Bie

    (Chinese Academy of Sciences)

  • Yuxuan Ma

    (Chinese Academy of Sciences)

  • Peter C. M. Zijl

    (Kennedy Krieger Institute
    The Johns Hopkins University School of Medicine)

  • Nirbhay N. Yadav

    (Kennedy Krieger Institute
    The Johns Hopkins University School of Medicine)

  • Xi Xu

    (Chinese Academy of Sciences)

  • Hairong Zheng

    (Chinese Academy of Sciences)

  • Dong Liang

    (Chinese Academy of Sciences)

  • Chao Zou

    (Chinese Academy of Sciences)

  • José L. Areta

    (Liverpool John Moores University)

  • Lin Chen

    (Xiamen University)

  • Yang Zhou

    (Chinese Academy of Sciences)

Abstract

Probing regional glycogen metabolism in humans non-invasively has been challenging due to a lack of sensitive approaches. Here we studied human muscle glycogen dynamics post-exercise with a spatial resolution of millimeters and temporal resolution of minutes, using relayed nuclear Overhauser effect (glycoNOE) MRI. Data at 5T showed a homogeneous distribution of glycogen in resting muscle, with an average concentration of 99 ± 13 mM. After plantar flexion exercise following fasting with recovery under fasting conditions, the calf muscle showed spatially heterogeneous glycogen depletion and repletion kinetics that correlated with the severity of this depletion. Three types of regional glycogen kinetics were observed: (i) single exponential repletion (type a); (ii) biphasic recovery of rapid repletion followed by additional depletion (type b); (iii) biphasic recovery where continued depletion is followed by an exponential recovery (type c). The study of the complex patterns of glycogen kinetics suggests that glycogen breakdown may be quantitatively important during the initial recovery.

Suggested Citation

  • Chongxue Bie & Yuxuan Ma & Peter C. M. Zijl & Nirbhay N. Yadav & Xi Xu & Hairong Zheng & Dong Liang & Chao Zou & José L. Areta & Lin Chen & Yang Zhou, 2024. "In vivo imaging of glycogen in human muscle," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-55132-x
    DOI: 10.1038/s41467-024-55132-x
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