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On the origin of mitosis-derived human embryo aneuploidy

Author

Listed:
  • Jiyeon Leem

    (Yale University)

  • Madison Gowett

    (Yale University)

  • Sarah Bolarinwa

    (Yale University)

  • Binyam Mogessie

    (Yale University)

Abstract

Chromosome segregation errors are common in the early stages of human embryonic development. By examining the first mitotic divisions of human embryos using live cell imaging, three recent studies identify spindle architecture and positioning features that could provide insights into why early embryos are predisposed to chromosomal abnormalities.

Suggested Citation

  • Jiyeon Leem & Madison Gowett & Sarah Bolarinwa & Binyam Mogessie, 2024. "On the origin of mitosis-derived human embryo aneuploidy," Nature Communications, Nature, vol. 15(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54953-0
    DOI: 10.1038/s41467-024-54953-0
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    References listed on IDEAS

    as
    1. Volodymyr Porokh & Drahomíra Kyjovská & Martina Martonová & Tereza Klenková & Pavel Otevřel & Soňa Kloudová & Zuzana Holubcová, 2024. "Zygotic spindle orientation defines cleavage pattern and nuclear status of human embryos," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Yuki Ono & Hiromitsu Shirasawa & Kazumasa Takahashi & Mayumi Goto & Takahiro Ono & Taichi Sakaguchi & Motonari Okabe & Takeo Hirakawa & Takuya Iwasawa & Akiko Fujishima & Tae Sugawara & Kenichi Makino, 2024. "Shape of the first mitotic spindles impacts multinucleation in human embryos," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
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