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Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years

Author

Listed:
  • Michelle A. Neller

    (QIMR Berghofer Medical Research Institute)

  • George R. Ambalathingal

    (QIMR Berghofer Medical Research Institute)

  • Nada Hamad

    (University of Notre Dame)

  • Joe Sasadeusz

    (University of Notre Dame)

  • Rebecca Pearson

    (University of Notre Dame)

  • Chien-Li Holmes-Liew

    (Royal Adelaide Hospital)

  • Deepak Singhal

    (Royal Adelaide Hospital)

  • Matthew Tunbridge

    (Royal Adelaide Hospital)

  • Wei Yang Ng

    (Royal Adelaide Hospital)

  • Kirsty Sharplin

    (Royal Adelaide Hospital)

  • Andrew Moore

    (Queensland Children’s Hospital)

  • David Deambrosis

    (Queensland Children’s Hospital)

  • Trisha Soosay-Raj

    (Queensland Children’s Hospital)

  • Peter McNaughton

    (Queensland Children’s Hospital)

  • Morag Whyte

    (Queensland Children’s Hospital)

  • Chris Fraser

    (Queensland Children’s Hospital)

  • Andrew Grigg

    (Heidelberg)

  • David Kliman

    (St Leonards)

  • Ashish Bajel

    (University of Melbourne
    Parkville)

  • Katherine Cummins

    (University of Melbourne
    Parkville)

  • Mark Dowling

    (University of Melbourne
    Parkville)

  • Zhi Han Yeoh

    (University of Melbourne
    Parkville)

  • Simon J. Harrison

    (University of Melbourne
    Parkville)

  • Amit Khot

    (University of Melbourne
    Parkville)

  • Sarah Tan

    (University of Melbourne
    Parkville)

  • Izanne Roos

    (University of Melbourne
    Parkville)

  • Ray Mun Koo

    (University of Melbourne
    Parkville)

  • Sara Dohrmann

    (University of Melbourne
    Parkville)

  • David Ritchie

    (University of Melbourne
    Parkville)

  • Brynn Wainstein

    (Sydney Children’s Hospital)

  • Karen McCleary

    (Sydney Children’s Hospital)

  • Adam Nelson

    (Sydney Children’s Hospital)

  • Bradley Gardiner

    (Melbourne)

  • Shafqat Inam

    (Melbourne)

  • Xavier Badoux

    (St George Public Hospital)

  • Kris Ma

    (Westmead Hospital)

  • Claudia Toro

    (Royal Children’s Hospital Melbourne)

  • Diane Hanna

    (Royal Children’s Hospital Melbourne)

  • David Hughes

    (Royal Children’s Hospital Melbourne)

  • Rachel Conyers

    (Royal Children’s Hospital Melbourne)

  • Theresa Cole

    (Royal Children’s Hospital Melbourne)

  • Shiqi Stacie Wang

    (Royal Children’s Hospital Melbourne)

  • Lynette Chee

    (Royal Children’s Hospital Melbourne)

  • Jacqueline Fleming

    (Royal Children’s Hospital Melbourne)

  • Ashley Irish

    (Fiona Stanley Hospital)

  • Duncan Purtill

    (Fiona Stanley Hospital)

  • Julian Cooney

    (Fiona Stanley Hospital)

  • Peter Shaw

    (The Children’s Hospital at Westmead)

  • Siok-Keen Tey

    (QIMR Berghofer Medical Research Institute
    Royal Brisbane and Women’s Hospital)

  • Stewart Hunt

    (Royal Brisbane and Women’s Hospital)

  • Elango Subramonia Pillai

    (Royal Brisbane and Women’s Hospital)

  • George John

    (Royal Brisbane and Women’s Hospital)

  • Michelle Ng

    (Perth Children’s Hospital)

  • Shanti Ramachandran

    (Perth Children’s Hospital)

  • Peter Hopkins

    (The Prince Charles Hospital
    The University of Queensland Medical School)

  • Daniel Chambers

    (The Prince Charles Hospital)

  • Scott Campbell

    (Princess Alexandra Hospital)

  • Ross Francis

    (Princess Alexandra Hospital)

  • Nicole Isbel

    (Princess Alexandra Hospital)

  • Paula Marlton

    (Princess Alexandra Hospital)

  • Hilary Reddiex

    (QIMR Berghofer Medical Research Institute)

  • Katherine K. Matthews

    (QIMR Berghofer Medical Research Institute)

  • Meggie Voogt

    (QIMR Berghofer Medical Research Institute)

  • Archana Panikkar

    (QIMR Berghofer Medical Research Institute)

  • Leone Beagley

    (QIMR Berghofer Medical Research Institute)

  • Sweera Rehan

    (QIMR Berghofer Medical Research Institute)

  • Shannon Best

    (QIMR Berghofer Medical Research Institute)

  • Jyothy Raju

    (QIMR Berghofer Medical Research Institute)

  • Laetitia Texier

    (QIMR Berghofer Medical Research Institute)

  • Pauline Crooks

    (QIMR Berghofer Medical Research Institute)

  • Matthew Solomon

    (QIMR Berghofer Medical Research Institute)

  • Lea Lekieffre

    (QIMR Berghofer Medical Research Institute)

  • Sriganesh Srihari

    (QIMR Berghofer Medical Research Institute)

  • Corey Smith

    (QIMR Berghofer Medical Research Institute)

  • Rajiv Khanna

    (QIMR Berghofer Medical Research Institute)

Abstract

Adoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis of 78 patients from 19 hospitals across Australia and New Zealand, treated over the last 15 years with “off-the-shelf” allogeneic T cells directed to a combination of Epstein–Barr virus (EBV), cytomegalovirus (CMV), BK polyomavirus (BKV), John Cunningham virus (JCV) and/or adenovirus (AdV) under the Australian Therapeutic Goods Administration’s Special Access Scheme. Most patients had severe post-transplant viral complications, including drug-resistant end-organ CMV disease, BKV-associated haemorrhagic cystitis and EBV-driven post-transplant lymphoproliferative disorder. Adoptive immunotherapy is well tolerated with few adverse effects. Importantly, 46/71 (65%) patients show definitive clinical improvement including reduction in viral load, clinical symptoms and complete resolution of end-organ disease. In addition, seven high-risk patients remain disease free. Based on this long-term encouraging clinical experience, we propose that a dedicated nationally funded centre for anti-viral cellular therapies should be considered to provide T cell therapies for critically ill patients for compassionate use.

Suggested Citation

  • Michelle A. Neller & George R. Ambalathingal & Nada Hamad & Joe Sasadeusz & Rebecca Pearson & Chien-Li Holmes-Liew & Deepak Singhal & Matthew Tunbridge & Wei Yang Ng & Kirsty Sharplin & Andrew Moore &, 2024. "Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54595-2
    DOI: 10.1038/s41467-024-54595-2
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