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Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans

Author

Listed:
  • Takahiro Osada

    (Juntendo University School of Medicine)

  • Koji Nakajima

    (Juntendo University School of Medicine
    The University of Tokyo School of Medicine)

  • Tomohiko Shirokoshi

    (Juntendo University School of Medicine
    The University of Tokyo School of Medicine)

  • Akitoshi Ogawa

    (Juntendo University School of Medicine)

  • Satoshi Oka

    (Juntendo University School of Medicine)

  • Koji Kamagata

    (Juntendo University School of Medicine)

  • Shigeki Aoki

    (Juntendo University School of Medicine)

  • Yasushi Oshima

    (The University of Tokyo School of Medicine)

  • Sakae Tanaka

    (The University of Tokyo School of Medicine)

  • Seiki Konishi

    (Juntendo University School of Medicine
    Juntendo University School of Medicine
    Juntendo University School of Medicine
    Juntendo University School of Medicine)

Abstract

Inhibiting prepotent responses in the face of external stop signals requires complex information processing, from perceptual to control processing. However, the cerebral circuits underlying these processes remain elusive. In this study, we used neuroimaging and brain stimulation to investigate the interplay between human brain regions during response inhibition at the whole-brain level. Magnetic resonance imaging suggested a sequential four-step processing pathway: initiating from the primary visual cortex (V1), progressing to the dorsal anterior insula (daINS), then involving two essential regions in the inferior frontal cortex (IFC), namely the ventral posterior IFC (vpIFC) and anterior IFC (aIFC), and reaching the basal ganglia (BG)/primary motor cortex (M1). A combination of ultrasound stimulation and time-resolved magnetic stimulation elucidated the causal influence of daINS on vpIFC and the unidirectional dependence of aIFC on vpIFC. These results unveil asymmetric pathways in the insular-prefrontal cortex and outline the macroscopic cerebral circuits for response inhibition: V1→daINS→vpIFC/aIFC→BG/M1.

Suggested Citation

  • Takahiro Osada & Koji Nakajima & Tomohiko Shirokoshi & Akitoshi Ogawa & Satoshi Oka & Koji Kamagata & Shigeki Aoki & Yasushi Oshima & Sakae Tanaka & Seiki Konishi, 2024. "Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54564-9
    DOI: 10.1038/s41467-024-54564-9
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