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Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level

Author

Listed:
  • Carrie Corkish

    (Trinity Biomedical Sciences Institute, Trinity College Dublin)

  • Cristhiane Favero Aguiar

    (Trinity Biomedical Sciences Institute, Trinity College Dublin)

  • David K. Finlay

    (Trinity Biomedical Sciences Institute, Trinity College Dublin
    Trinity Biomedical Sciences Institute, Trinity College Dublin)

Abstract

Tissue-resident innate immune cells have important functions in both homeostasis and pathological states. Despite advances in the field, analyzing the metabolism of tissue-resident innate lymphocytes is still challenging. The small number of tissue-resident innate lymphocytes such as ILC, NK, iNKT and γδ T cells poses additional obstacles in their metabolic studies. In this review, we summarize the current understanding of innate lymphocyte metabolism and discuss potential pitfalls associated with the current methodology relying predominantly on in vitro cultured cells or bulk-level comparison. Meanwhile, we also summarize and advocate for the development and adoption of single-cell metabolic assays to accurately profile the metabolism of tissue-resident immune cells directly ex vivo.

Suggested Citation

  • Carrie Corkish & Cristhiane Favero Aguiar & David K. Finlay, 2024. "Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54516-3
    DOI: 10.1038/s41467-024-54516-3
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