IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-54405-9.html
   My bibliography  Save this article

High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China

Author

Listed:
  • Xin Lu

    (Chinese Center for Disease Control and Prevention)

  • Ming Luo

    (Yulin Center for Disease Control and Prevention)

  • Mengyu Wang

    (Chinese Center for Disease Control and Prevention
    Shandong University)

  • Zhemin Zhou

    (Chinese Center for Disease Control and Prevention
    Soochow University)

  • Jialiang Xu

    (Beijing Technology and Business University)

  • Zhenpeng Li

    (Chinese Center for Disease Control and Prevention)

  • Yao Peng

    (Chinese Center for Disease Control and Prevention)

  • Yuan Zhang

    (Chinese Center for Disease Control and Prevention)

  • Fangyu Ding

    (Chinese Academy of Sciences)

  • Dong Jiang

    (Chinese Academy of Sciences)

  • Changyu Zhou

    (Yulin Center for Disease Control and Prevention)

  • Liya Yang

    (Chinese Center for Disease Control and Prevention
    Beijing Technology and Business University)

  • Wenxuan Zhao

    (Chinese Center for Disease Control and Prevention)

  • Tian Ma

    (Chinese Academy of Sciences)

  • Bo Pang

    (Chinese Center for Disease Control and Prevention)

  • Meiying Yan

    (Chinese Center for Disease Control and Prevention)

  • Yongning Wu

    (China National Center for Food Safety Risk Assessment)

  • Yannong Wu

    (Yulin Center for Disease Control and Prevention)

  • Biao Kan

    (Chinese Center for Disease Control and Prevention
    Shandong University)

Abstract

Food workers have frequent contact with unprocessed foods, but their carriage of Salmonella and potential influence on public health have not been comprehensively assessed. We investigated Salmonella carriage among food workers compared with non-food workers based on occupational health screening of 260,315 asymptomatic workers over an 8-year surveillance period in Yulin, China. We confirmed that healthy carriers serve as natural reservoirs for Salmonella, with higher carriage rates in food workers than non-food workers. The isolates from food workers also exhibited greater serovar diversity and likely higher levels of antimicrobial resistance than those from non-food workers. Factors such as meteorological, social, and hygiene factors potentially influenced the carriage rate. Genomic analysis revealed a consistent increase in antimicrobial resistance genes among Salmonella isolates over the study period, with the majority of these antimicrobial resistance genes located on plasmids. Additionally, we identified numerous closely related bacterial clusters, which might reflect clusters of hidden local foodborne infections. This study underscores the elevated risk posed by food workers in the persistence and dissemination of Salmonella as vectors/fomites. Enhanced monitoring and targeted interventions in this group may reduce the dissemination of pathogens and antimicrobial resistance genes.

Suggested Citation

  • Xin Lu & Ming Luo & Mengyu Wang & Zhemin Zhou & Jialiang Xu & Zhenpeng Li & Yao Peng & Yuan Zhang & Fangyu Ding & Dong Jiang & Changyu Zhou & Liya Yang & Wenxuan Zhao & Tian Ma & Bo Pang & Meiying Yan, 2024. "High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54405-9
    DOI: 10.1038/s41467-024-54405-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-54405-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-54405-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Shaoting Li & Yingshu He & David Ames Mann & Xiangyu Deng, 2021. "Global spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Iman Yassine & Sophie Lefèvre & Elisabeth E. Hansen & Corinne Ruckly & Isabelle Carle & Monique Lejay-Collin & Laëtitia Fabre & Rayane Rafei & Dominique Clermont & Maria Pardos Gandara & Fouad Dabbous, 2022. "Population structure analysis and laboratory monitoring of Shigella by core-genome multilocus sequence typing," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sophie Lefèvre & Elisabeth Njamkepo & Sarah Feldman & Corinne Ruckly & Isabelle Carle & Monique Lejay-Collin & Laëtitia Fabre & Iman Yassine & Lise Frézal & Maria Pardos de la Gandara & Arnaud Fontane, 2023. "Rapid emergence of extensively drug-resistant Shigella sonnei in France," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54405-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.