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The outcomes of SGLT-2 inhibitor utilization in diabetic kidney transplant recipients

Author

Listed:
  • Jia-Yuh Sheu

    (National Taiwan University Hospital)

  • Li-Yang Chang

    (National Taiwan University)

  • Jui-Yi Chen

    (Chi-Mei Medical Center
    Chia Nan University of Pharmacy and Science)

  • Heng-Chih Pan

    (National Taiwan University
    Chang Gung University College of Medicine
    Keelung Chang Gung Memorial Hospital
    Keelung Chang Gung Memorial Hospital)

  • Chi-Shin Tseng

    (National Taiwan University Hospital
    National Taiwan University Hospital)

  • Jeff S. Chueh

    (National Taiwan University Hospital
    National Taiwan University
    National Taiwan University Hospital)

  • Vin-Cent Wu

    (National Taiwan University Hospital
    National Taiwan University Hospital
    National Taiwan University Hospital Study Group of Acute Renal Failure and Taiwan Consortium for Acute Kidney Injury and Renal Diseases)

Abstract

Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) have demonstrated efficacy in reducing cardiovascular events and potentially improving kidney function in diabetic patients. This investigation analyzes the TriNetX database to assess the efficacy of SGLT-2i in diabetic kidney transplant recipients (KTR) concerning all-cause mortality, major adverse cardiac events (MACE), and major adverse kidney events (MAKE). The study includes type 2 diabetic patients over 18 who underwent kidney transplants between June 1, 2015, and June 1, 2023, with a focus on SGLT-2i use within the first three months post-transplant. After propensity score matching, the study compares 1970 SGLT-2i users with matched non-users. With a median follow-up of 3.4 years, SGLT-2i users showed significantly lower rates of all-cause mortality (adjusted hazard ratio [aHR]: 0.32), MACE (aHR: 0.48), and MAKE (aHR: 0.52). These findings indicate that SGLT-2i significantly reduces mortality and adverse events in diabetic KTR, underscoring its potential to improve post-transplant outcomes.

Suggested Citation

  • Jia-Yuh Sheu & Li-Yang Chang & Jui-Yi Chen & Heng-Chih Pan & Chi-Shin Tseng & Jeff S. Chueh & Vin-Cent Wu, 2024. "The outcomes of SGLT-2 inhibitor utilization in diabetic kidney transplant recipients," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54171-8
    DOI: 10.1038/s41467-024-54171-8
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