IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-53842-w.html
   My bibliography  Save this article

Effectiveness of BNT162b2 XBB vaccine in the US Veterans Affairs Healthcare System

Author

Listed:
  • Aisling R. Caffrey

    (Providence Veterans Affairs Healthcare System
    Providence Veterans Affairs Healthcare System
    University of Rhode Island
    Brown University)

  • Haley J. Appaneal

    (Providence Veterans Affairs Healthcare System
    Providence Veterans Affairs Healthcare System
    University of Rhode Island)

  • Vrishali V. Lopes

    (Providence Veterans Affairs Healthcare System)

  • Laura Puzniak

    (Pfizer Inc. New York)

  • Evan J. Zasowski

    (Pfizer Inc. New York)

  • Luis Jodar

    (Pfizer Inc. New York)

  • Kerry L. LaPlante

    (Providence Veterans Affairs Healthcare System
    Providence Veterans Affairs Healthcare System
    University of Rhode Island)

  • John M. McLaughlin

    (Pfizer Inc. New York)

Abstract

Data evaluating effectiveness of XBB.1.5-adapted vaccines against JN.1-related endpoints are scarce. This nationwide test-negative case-control study within the US Veterans Affairs Healthcare System aims to estimate vaccine effectiveness (VE) of BNT162b2 XBB.1.5-adapted vaccine compared to not receiving an XBB vaccine of any kind against COVID-19 hospitalization, emergency department or urgent care visits (ED/UC), and outpatient visits. Between September 25, 2023 and January 31, 2024, effectiveness was 24–35% during a period of JN.1 predominance and 50–61% during XBB predominance across all outcomes. VE within 60 days of vaccination during the likely JN.1 period was 32% (95% confidence interval 3–52%) against hospitalization, 41% (23–54%) against ED/UC visits, and 31% (1–52%) against outpatient visits. Corresponding VE during the likely XBB period was 62% (44–74%), 52% (37–63%), and 50% (25–66%) by setting, respectively. Here, we show the importance of strain match to maximize the public health impact of COVID-19 vaccination.

Suggested Citation

  • Aisling R. Caffrey & Haley J. Appaneal & Vrishali V. Lopes & Laura Puzniak & Evan J. Zasowski & Luis Jodar & Kerry L. LaPlante & John M. McLaughlin, 2024. "Effectiveness of BNT162b2 XBB vaccine in the US Veterans Affairs Healthcare System," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53842-w
    DOI: 10.1038/s41467-024-53842-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-53842-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-53842-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53842-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.