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Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023

Author

Listed:
  • Paola Cristina Resende

    (Oswaldo Cruz Foundation)

  • Dennis M. Junqueira

    (Universidade Federal de Santa Maria (UFSM))

  • Caroline Tochetto

    (Embrapa Suínos e Aves)

  • Maria Ogrzewalska

    (Oswaldo Cruz Foundation)

  • Fernando C. Motta

    (Oswaldo Cruz Foundation)

  • Jonathan Lopes

    (Oswaldo Cruz Foundation)

  • Luciana Appolinario

    (Oswaldo Cruz Foundation)

  • Larissa Macedo

    (Oswaldo Cruz Foundation)

  • Braulia Caetano

    (Oswaldo Cruz Foundation)

  • Aline Matos

    (Oswaldo Cruz Foundation)

  • Thauane Silva

    (Oswaldo Cruz Foundation)

  • Elisa Cavalcante Pereira

    (Oswaldo Cruz Foundation)

  • Leticia Ferreira Lima

    (Oswaldo Cruz Foundation)

  • Irina Riediger

    (Laboratório Central do Estado do Paraná (LACEN-PR))

  • Maria do Carmo Debur

    (Laboratório Central do Estado do Paraná (LACEN-PR))

  • Guilherme Nardi Becker

    (Laboratório Central do Estado do Paraná (LACEN-PR))

  • Aline Andrade

    (Laboratório Central do Estado do Paraná (LACEN-PR))

  • Acácia Maria Lourenço Francisco Nasr

    ((SESA/PR))

  • Rosana Aparecida Piler

    ((SESA/PR))

  • Ana Carolina Dalla Vecchia

    ((SESA/PR))

  • Walquíria Almeida

    (Ministério da Saúde)

  • David Brown

    (Oswaldo Cruz Foundation)

  • Rejane Schaefer

    (Embrapa Suínos e Aves)

  • Marilda M. Siqueira

    (Oswaldo Cruz Foundation)

Abstract

Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild and 2 severe cases, including 1 death) detected in Paraná, Brazil, during 2020–2023. Genomes recovered were closely related to Brazilian swIAVs of three major lineages (1 A.3.3.2/pdm09, 1B/human-like, and H3.1990.5), including three H1N1v, two H1N2v, two H3N2v and one H1v. Five H1v were closely related to pdm09 lineage, one H1v (H1N2v) grouped within 1B.2.3 clade, and the two H3v grouped within a clade composed exclusively of Brazilian H3 swIAV (clade H3.1990.5.1). Internal gene segments were closely related to H1N1pdm09 isolated from pigs. IAV variant rarely result in sustained transmission between people, however the potential to develop such ability is of concern and must not be underestimated. This study brings into focus the need for continuous influenza surveillance and timely risk assessment.

Suggested Citation

  • Paola Cristina Resende & Dennis M. Junqueira & Caroline Tochetto & Maria Ogrzewalska & Fernando C. Motta & Jonathan Lopes & Luciana Appolinario & Larissa Macedo & Braulia Caetano & Aline Matos & Thaua, 2024. "Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53815-z
    DOI: 10.1038/s41467-024-53815-z
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