IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-53768-3.html
   My bibliography  Save this article

Fine-tuning levels of filamins a and b as a specific mechanism sustaining Th2 lymphocyte functions

Author

Listed:
  • Kilian Maire

    (University of Toulouse, CNRS, Inserm, UPS)

  • Léa Chamy

    (University of Toulouse, CNRS, Inserm, UPS)

  • Samira Ghazali

    (University of Toulouse, CNRS, Inserm, UPS)

  • Manon Carratala-Lasserre

    (University of Toulouse, CNRS, Inserm, UPS)

  • Margot Zahm

    (University of Toulouse, CNRS, Inserm, UPS)

  • Clément Bouisset

    (University of Toulouse, CNRS, Inserm, UPS)

  • Arnaud Métais

    (Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS)

  • Lucie Combes-Soia

    (Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS)

  • Lidia Fuente-Vizuete

    (University of Toulouse, CNRS, Inserm, UPS)

  • Hussein Trad

    (University of Toulouse, CNRS, Inserm, UPS)

  • Adeline Chaubet

    (University of Toulouse, CNRS, Inserm, UPS)

  • Magali Savignac

    (University of Toulouse, CNRS, Inserm, UPS)

  • Anne Gonzalez de Peredo

    (Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS)

  • Arun Subramaniam

    (Sanofi Immunology and Inflammation Research Therapeutic Area)

  • Olivier Joffre

    (University of Toulouse, CNRS, Inserm, UPS)

  • Pierre G. Lutz

    (University of Toulouse, CNRS, Inserm, UPS)

  • Isabelle Lamsoul

    (University of Toulouse, CNRS, Inserm, UPS)

Abstract

Augmenting the portfolio of therapeutics for type 2-driven diseases is crucial to address unmet clinical needs and to design personalized treatment schemes. An attractive therapy for such diseases would consist in targeting the recruitment of T helper 2 (Th2) lymphocytes to inflammatory sites. Herein, we show the degradation of filamins (FLN) a and b by the ASB2α E3 ubiquitin ligase as a mechanism sustaining Th2 lymphocyte functions. Low levels of FLNa and FLNb confer an elongated shape to Th2 lymphocytes associated with efficient αVβ3 integrin-dependent cell migration. Genes encoding the αVβ3 integrin and ASB2α belong to the core of Th2-specific genes. Using genetically modified mice, we find that increasing the levels of FLNa and FLNb in Th2 lymphocytes reduces airway inflammation through diminished Th2 lymphocyte recruitment in inflamed lungs. Collectively, our results highlight ASB2α and its substrates FLNa and FLNb to alter Th2 lymphocyte-mediated responses.

Suggested Citation

  • Kilian Maire & Léa Chamy & Samira Ghazali & Manon Carratala-Lasserre & Margot Zahm & Clément Bouisset & Arnaud Métais & Lucie Combes-Soia & Lidia Fuente-Vizuete & Hussein Trad & Adeline Chaubet & Maga, 2024. "Fine-tuning levels of filamins a and b as a specific mechanism sustaining Th2 lymphocyte functions," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53768-3
    DOI: 10.1038/s41467-024-53768-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-53768-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-53768-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53768-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.