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Exposing 24-hour cycles in bile acids of male humans

Author

Listed:
  • Adesola T. Bello

    (Imperial College London)

  • Magali H. Sarafian

    (Bioaster Microbiology Technology Institute)

  • Elizabeth A. Wimborne

    (University of Southampton)

  • Benita Middleton

    (Guildford)

  • Victoria L. Revell

    (Guildford
    University of Surrey)

  • Florence I. Raynaud

    (The Institute of Cancer Research)

  • Namrata R. Chowdhury

    (Guildford)

  • Daan R. Veen

    (Guildford)

  • Debra J. Skene

    (Guildford)

  • Jonathan R. Swann

    (Imperial College London
    University of Southampton)

Abstract

Bile acids are trans-genomic molecules arising from the concerted metabolism of the human host and the intestinal microbiota and are important for digestion, energy homeostasis and metabolic regulation. While diurnal variation has been demonstrated in the enterohepatic circulation and the gut microbiota, existing human data are poorly resolved, and the influence of the host circadian system has not been determined. Using entrained laboratory protocols, we demonstrate robust daily rhythms in the circulating bile acid pool in healthy male participants. We identify temporal relationships between bile acids and plasma lipids and show that these relationships are lost following sleep deprivation. We also highlight that bile acid rhythmicity is predominantly lost when environmental timing cues are held constant. Here we show that the environment is a stronger determinant of these temporal dynamics than the intrinsic circadian system of the host. This has significance for the intimate relationship between circadian timing and metabolism.

Suggested Citation

  • Adesola T. Bello & Magali H. Sarafian & Elizabeth A. Wimborne & Benita Middleton & Victoria L. Revell & Florence I. Raynaud & Namrata R. Chowdhury & Daan R. Veen & Debra J. Skene & Jonathan R. Swann, 2024. "Exposing 24-hour cycles in bile acids of male humans," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53673-9
    DOI: 10.1038/s41467-024-53673-9
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    References listed on IDEAS

    as
    1. Mitsuhiro Watanabe & Sander M. Houten & Chikage Mataki & Marcelo A. Christoffolete & Brian W. Kim & Hiroyuki Sato & Nadia Messaddeq & John W. Harney & Osamu Ezaki & Tatsuhiko Kodama & Kristina Schoonj, 2006. "Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation," Nature, Nature, vol. 439(7075), pages 484-489, January.
    2. Marjolein Heddes & Baraa Altaha & Yunhui Niu & Sandra Reitmeier & Karin Kleigrewe & Dirk Haller & Silke Kiessling, 2022. "The intestinal clock drives the microbiome to maintain gastrointestinal homeostasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    Full references (including those not matched with items on IDEAS)

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