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Visible-light-mediated deoxygenative transformation of 1,2-dicarbonyl compounds through energy transfer process

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  • Yun-Xuan Luo

    (Huazhong University of Science and Technology (HUST))

  • Jie Huang

    (Huazhong University of Science and Technology (HUST))

  • Guojiao Wu

    (Huazhong University of Science and Technology (HUST))

  • Xiang-Ying Tang

    (Huazhong University of Science and Technology (HUST))

  • Jin-Ping Qu

    (Huazhong University of Science and Technology (HUST)
    Guangzhou)

Abstract

Through the energy transfer process, mild transformations can be achieved that are often difficult to realize under thermodynamic conditions. Herein, a visible-light-driven deoxygenative coupling of 1,2-dicarbonyl compounds for C–O, C–S, and C–N bonds construction is developed via triplet state 1,2-dicarbonyls, affording a wide range of α-functionalized ketones/esters under transition-metal and external photocatalyst free conditions. The usefulness of this method is demonstrated by gram-scale synthesis, late-stage functionalization of various carboxylic acid drugs, and the synthesis of natural products and drug molecules.

Suggested Citation

  • Yun-Xuan Luo & Jie Huang & Guojiao Wu & Xiang-Ying Tang & Jin-Ping Qu, 2024. "Visible-light-mediated deoxygenative transformation of 1,2-dicarbonyl compounds through energy transfer process," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53635-1
    DOI: 10.1038/s41467-024-53635-1
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