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Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction

Author

Listed:
  • Alice Braun

    (Berlin
    Cambridge)

  • Sudhanshu Shekhar

    (University of North Carolina at Chapel Hill
    West Lafayette)

  • Daniel F. Levey

    (Yale School of Medicine
    Veterans Affairs Connecticut Healthcare Center)

  • Peter Straub

    (Vanderbilt University Medical Center
    Vanderbilt University Medical Center)

  • Julia Kraft

    (Berlin
    Cambridge)

  • Georgia M. Panagiotaropoulou

    (Berlin
    Cambridge)

  • Karl Heilbron

    (Berlin
    Cambridge)

  • Swapnil Awasthi

    (Berlin
    Cambridge)

  • Rafael Meleka Hanna

    (Berlin
    Berlin)

  • Sarah Hoffmann

    (Berlin
    Berlin)

  • Maike Stein

    (Berlin
    Berlin
    Boston)

  • Sophie Lehnerer

    (Berlin
    Berlin)

  • Philipp Mergenthaler

    (Berlin
    Berlin
    Berlin
    University of Oxford)

  • Abdelrahman G. Elnahas

    (University of Tartu)

  • Apostolia Topaloudi

    (West Lafayette)

  • Maria Koromina

    (New York
    New York
    New York)

  • Teemu Palviainen

    (University of Helsinki)

  • Bergrun Asbjornsdottir

    (Inc.)

  • Hreinn Stefansson

    (Inc.)

  • Astros Th. Skuladóttir

    (Inc.)

  • Ingileif Jónsdóttir

    (Inc.)

  • Kari Stefansson

    (Inc.)

  • Kadri Reis

    (University of Tartu)

  • Tõnu Esko

    (University of Tartu)

  • Aarno Palotie

    (University of Helsinki)

  • Frank Leypoldt

    (Kiel)

  • Murray B. Stein

    (La Jolla
    San Diego)

  • Pierre Fontanillas

    (Sunnyvale)

  • Jaakko Kaprio

    (University of Helsinki)

  • Joel Gelernter

    (Yale School of Medicine
    Veterans Affairs Connecticut Healthcare Center)

  • Lea K. Davis

    (Vanderbilt University Medical Center
    Vanderbilt University Medical Center
    New York)

  • Peristera Paschou

    (West Lafayette)

  • Martijn R. Tannemaat

    (Department of Neurology)

  • Jan J.G.M. Verschuuren

    (Department of Neurology)

  • Gregor Kuhlenbäumer

    (Kiel
    Kiel)

  • Peter K. Gregersen

    (Manhasset)

  • Maartje G. Huijbers

    (Department of Neurology
    Department of Human Genetics)

  • Frauke Stascheit

    (Berlin
    Berlin)

  • Andreas Meisel

    (Berlin
    Berlin
    Berlin)

  • Stephan Ripke

    (Berlin
    Cambridge
    partner site Berlin/Potsdam)

Abstract

Myasthenia gravis (MG) is a rare autoantibody-mediated disease affecting the neuromuscular junction. We performed a genome-wide association study of 5708 MG cases and 432,028 controls of European ancestry and a replication study in 3989 cases and 226,643 controls provided by 23andMe Inc. We identified 12 independent genome-wide significant hits (P

Suggested Citation

  • Alice Braun & Sudhanshu Shekhar & Daniel F. Levey & Peter Straub & Julia Kraft & Georgia M. Panagiotaropoulou & Karl Heilbron & Swapnil Awasthi & Rafael Meleka Hanna & Sarah Hoffmann & Maike Stein & S, 2024. "Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53595-6
    DOI: 10.1038/s41467-024-53595-6
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