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Shuttle HAT for mild alkene transfer hydrofunctionalization

Author

Listed:
  • Tanner C. Jankins

    (ETH Zürich)

  • Philip M. Blank

    (ETH Zürich)

  • Andrea Brugnetti

    (ETH Zürich)

  • Philip Boehm

    (ETH Zürich)

  • Françoise A. Aouane

    (ETH Zürich)

  • Bill Morandi

    (ETH Zürich)

Abstract

Hydrogen atom transfer (HAT) from a metal-hydride is a reliable and powerful method for functionalizing unsaturated C–C bonds in organic synthesis. Cobalt hydrides (Co–H) have garnered significant attention in this field, where the weak Co–H bonds are most commonly generated in a catalytic fashion through a mixture of stoichiometric amounts of peroxide oxidant and silane reductant. Here we show that the reverse process of HAT to an alkene, i.e. hydrogen atom abstraction of a C–H adjacent to a radical, can be leveraged to generate catalytically active Co–H species in an application of shuttle catalysis coined shuttle HAT. This method obviates the need for stoichiometric reductant/oxidant mixtures thereby greatly simplifying the generation of Co–H. To demonstrate the generality of this shuttle HAT platform, five different reaction manifolds are shown, and the reaction can easily be scaled up to 100 mmol.

Suggested Citation

  • Tanner C. Jankins & Philip M. Blank & Andrea Brugnetti & Philip Boehm & Françoise A. Aouane & Bill Morandi, 2024. "Shuttle HAT for mild alkene transfer hydrofunctionalization," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53281-7
    DOI: 10.1038/s41467-024-53281-7
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    References listed on IDEAS

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    1. Samer Gnaim & Adriano Bauer & Hai-Jun Zhang & Longrui Chen & Cara Gannett & Christian A. Malapit & David E. Hill & David Vogt & Tianhua Tang & Ryan A. Daley & Wei Hao & Rui Zeng & Mathilde Quertenmont, 2022. "Cobalt-electrocatalytic HAT for functionalization of unsaturated C–C bonds," Nature, Nature, vol. 605(7911), pages 687-695, May.
    2. Yuji Kamei & Yusuke Seino & Yuto Yamaguchi & Tatsuhiko Yoshino & Satoshi Maeda & Masahiro Kojima & Shigeki Matsunaga, 2021. "Silane- and peroxide-free hydrogen atom transfer hydrogenation using ascorbic acid and cobalt-photoredox dual catalysis," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
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