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Prospective assessment of circulating tumor DNA in patients with metastatic uveal melanoma treated with tebentafusp

Author

Listed:
  • Manuel Rodrigues

    (Institut Curie
    PSL Research University)

  • Toulsie Ramtohul

    (PSL Research University)

  • Aurore Rampanou

    (Institut Curie)

  • José Luis Sandoval

    (Institut Curie)

  • Alexandre Houy

    (PSL Research University)

  • Vincent Servois

    (PSL Research University)

  • Léah Mailly-Giacchetti

    (PSL Research University)

  • Gaelle Pierron

    (PSL Research University)

  • Anne Vincent-Salomon

    (PSL Research University)

  • Nathalie Cassoux

    (PSL Research University)

  • Pascale Mariani

    (PSL Research University)

  • Caroline Dutriaux

    (Hôpital Saint André Centre Hospitalier Universitaire)

  • Marc Pracht

    (Centre Eugène Marquis)

  • Thomas Ryckewaert

    (Oscar Lambret Center)

  • Jean-Emmanuel Kurtz

    (ICANS)

  • Sergio Roman-Roman

    (PSL Research University
    PSL Research University)

  • Sophie Piperno-Neumann

    (Institut Curie)

  • François-Clément Bidard

    (Institut Curie
    Institut Curie
    Paris-Saclay University)

  • Marc-Henri Stern

    (PSL Research University)

  • Shufang Renault

    (Institut Curie)

Abstract

Tebentafusp, a bispecific immune therapy, is the only drug that demonstrated an overall survival benefit in patients with metastatic uveal melanoma (MUM). Circulating tumor DNA (ctDNA) has emerged as a potential prognostic and predictive marker in the phase 3 IMCgp100-202 trial using multiplex PCR-based next-generation sequencing (NGS). In this study (NCT02866149), ctDNA dynamics were assessed using droplet digital PCR (ddPCR) in 69 MUM patients undergoing tebentafusp treatment. Notably, 61% of patients exhibited detectable ctDNA before treatment initiation, which was associated with shorter overall survival (median 12.9 months versus 40.5 months for patients with undetectable ctDNA; p

Suggested Citation

  • Manuel Rodrigues & Toulsie Ramtohul & Aurore Rampanou & José Luis Sandoval & Alexandre Houy & Vincent Servois & Léah Mailly-Giacchetti & Gaelle Pierron & Anne Vincent-Salomon & Nathalie Cassoux & Pasc, 2024. "Prospective assessment of circulating tumor DNA in patients with metastatic uveal melanoma treated with tebentafusp," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53145-0
    DOI: 10.1038/s41467-024-53145-0
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