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Regional tuning of photoreceptor adaptation in the primate retina

Author

Listed:
  • Aindrila Saha

    (University of Wisconsin
    University of Wisconsin)

  • Theodore Bucci

    (University of Wisconsin
    University of Wisconsin)

  • Jacob Baudin

    (University of Washington)

  • Raunak Sinha

    (University of Wisconsin
    University of Wisconsin
    University of Wisconsin)

Abstract

Adaptation in cone photoreceptors allows our visual system to effectively operate over an enormous range of light intensities. However, little is known about the properties of cone adaptation in the specialized region of the primate central retina called the fovea, which is densely packed with cones and mediates high-acuity central vision. Here we show that macaque foveal cones exhibit weaker and slower luminance adaptation compared to cones in the peripheral retina. We find that this difference in adaptive properties between foveal and peripheral cones is due to differences in the magnitude of a hyperpolarization-activated current, Ih. This Ih current regulates the strength and time course of luminance adaptation in peripheral cones where it is more prominent than in foveal cones. A weaker and slower adaptation in foveal cones helps maintain a higher sensitivity for a longer duration which may be well-suited for maximizing the collection of high-acuity information at the fovea during gaze fixation between rapid eye movements.

Suggested Citation

  • Aindrila Saha & Theodore Bucci & Jacob Baudin & Raunak Sinha, 2024. "Regional tuning of photoreceptor adaptation in the primate retina," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53061-3
    DOI: 10.1038/s41467-024-53061-3
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    References listed on IDEAS

    as
    1. Felice A. Dunn & Martin J. Lankheet & Fred Rieke, 2007. "Light adaptation in cone vision involves switching between receptor and post-receptor sites," Nature, Nature, vol. 449(7162), pages 603-606, October.
    2. Marcus H C Howlett & Robert G Smith & Maarten Kamermans, 2017. "A novel mechanism of cone photoreceptor adaptation," PLOS Biology, Public Library of Science, vol. 15(4), pages 1-28, April.
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