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Tumour-informed liquid biopsies to monitor advanced melanoma patients under immune checkpoint inhibition

Author

Listed:
  • Christopher Schroeder

    (University of Tübingen
    German Cancer Consortium (DKTK), partner site Tübingen, German Cancer Research Center (DKFZ))

  • Sergios Gatidis

    (University Hospital Tübingen)

  • Olga Kelemen

    (University of Tübingen)

  • Leon Schütz

    (University of Tübingen)

  • Irina Bonzheim

    (University Hospital Tübingen)

  • Francesc Muyas

    (University of Tübingen)

  • Peter Martus

    (Institute for Clinical Epidemiology and Applied Biostatistics (IKEaB))

  • Jakob Admard

    (University of Tübingen
    University of Tübingen)

  • Sorin Armeanu-Ebinger

    (University of Tübingen)

  • Brigitte Gückel

    (University Hospital Tübingen)

  • Thomas Küstner

    (University Hospital Tübingen)

  • Claus Garbe

    (University Hospital Tübingen)

  • Lukas Flatz

    (University Hospital Tübingen)

  • Christina Pfannenberg

    (University Hospital Tübingen)

  • Stephan Ossowski

    (University of Tübingen
    German Cancer Consortium (DKTK), partner site Tübingen, German Cancer Research Center (DKFZ)
    University of Tübingen
    University of Tübingen)

  • Andrea Forschner

    (University Hospital Tübingen)

Abstract

Immune checkpoint inhibitors (ICI) have significantly improved overall survival in melanoma patients. However, 60% experience severe adverse events and early response markers are lacking. Circulating tumour DNA (ctDNA) is a promising biomarker for treatment-response and recurrence detection. The prospective PET/LIT study included 104 patients with palliative combined or adjuvant ICI. Tumour-informed sequencing panels to monitor 30 patient-specific variants were designed and 321 liquid biopsies of 87 patients sequenced. Mean sequencing depth after deduplication using UMIs was 6000x and the error rate of UMI-corrected reads was 2.47×10−4. Variant allele fractions correlated with PET/CT MTV (rho=0.69), S100 (rho=0.72), and LDH (rho=0.54). A decrease of allele fractions between T1 and T2 was associated with improved PFS and OS in the palliative cohort (p = 0.008 and p

Suggested Citation

  • Christopher Schroeder & Sergios Gatidis & Olga Kelemen & Leon Schütz & Irina Bonzheim & Francesc Muyas & Peter Martus & Jakob Admard & Sorin Armeanu-Ebinger & Brigitte Gückel & Thomas Küstner & Claus , 2024. "Tumour-informed liquid biopsies to monitor advanced melanoma patients under immune checkpoint inhibition," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52923-0
    DOI: 10.1038/s41467-024-52923-0
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    References listed on IDEAS

    as
    1. Christopher Abbosh & Alexander M. Frankell & Thomas Harrison & Judit Kisistok & Aaron Garnett & Laura Johnson & Selvaraju Veeriah & Mike Moreau & Adrian Chesh & Tafadzwa L. Chaunzwa & Jakob Weiss & Mo, 2023. "Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA," Nature, Nature, vol. 616(7957), pages 553-562, April.
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