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The activating receptor NKG2D is an anti-fungal pattern recognition receptor

Author

Listed:
  • Yoav Charpak-Amikam

    (IMRIC)

  • Mark Kournos

    (IMRIC)

  • Rebecca Kotzur

    (IMRIC)

  • Batya Isaacson

    (IMRIC)

  • Tal Bagad Brenner

    (IMRIC)

  • Elidet Gomez-Cesar

    (IMRIC)

  • Ammar Abou-Kandil

    (Ramat-Aviv)

  • Ronen Ben-Ami

    (Tel Aviv University)

  • Maya Korem

    (Hadassah-Hebrew University Medical Center)

  • Nadia Guerra

    (Imperial College London)

  • Nir Osherov

    (Ramat-Aviv)

  • Ofer Mandelboim

    (IMRIC)

Abstract

NKG2D is a central activating receptor involved in target recognition and killing by Natural Killer and CD8+ T cells. The known role of NKG2D is to recognize a family of self-induced stress ligands that are upregulated on stressed cells such as cancerous or virally infected cells. Fungal pathogens are a major threat to human health, infecting more than a billion patients yearly and becoming more common and drug resistant. Here we show that NKG2D plays a critical role in the immune response against fungal infections. NKG2D can recognize fungal pathogens from most major families including Candida, Cryptococcus and Aspergillus species, and mice lacking NKG2D are extremely sensitive to fungal infections in models of both invasive and mucosal infections, making NKG2D an anti-fungal pattern recognition receptor.

Suggested Citation

  • Yoav Charpak-Amikam & Mark Kournos & Rebecca Kotzur & Batya Isaacson & Tal Bagad Brenner & Elidet Gomez-Cesar & Ammar Abou-Kandil & Ronen Ben-Ami & Maya Korem & Nadia Guerra & Nir Osherov & Ofer Mande, 2024. "The activating receptor NKG2D is an anti-fungal pattern recognition receptor," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52913-2
    DOI: 10.1038/s41467-024-52913-2
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    References listed on IDEAS

    as
    1. Shu Shun Li & Henry Ogbomo & Michael K. Mansour & Richard F. Xiang & Lian Szabo & Fay Munro & Priyanka Mukherjee & Roy A. Mariuzza & Matthias Amrein & Jatin M. Vyas & Stephen M. Robbins & Christopher , 2018. "Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    2. Yoav Charpak-Amikam & Tom Lapidus & Batya Isaacson & Alexandra Duev-Cohen & Tal Levinson & Adi Elbaz & Francesca Levi-Schaffer & Nir Osherov & Gilad Bachrach & Lois L. Hoyer & Maya Korem & Ronen Ben-A, 2022. "Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
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    1. Yoav Charpak-Amikam & Tom Lapidus & Batya Isaacson & Alexandra Duev-Cohen & Tal Levinson & Adi Elbaz & Francesca Levi-Schaffer & Nir Osherov & Gilad Bachrach & Lois L. Hoyer & Maya Korem & Ronen Ben-A, 2022. "Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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