IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-52855-9.html
   My bibliography  Save this article

A visible light-activated azo-fluorescent switch for imaging-guided and light-controlled release of antimycotics

Author

Listed:
  • Yurou Huang

    (Central China Normal University)

  • Xiaoyan Zeng

    (Central China Normal University)

  • Xiaoxie Ma

    (Central China Normal University)

  • Zibo Lin

    (Central China Normal University)

  • Jiayue Sun

    (Central China Normal University)

  • Wang Xiao

    (Central China Normal University)

  • Sheng Hua Liu

    (Central China Normal University)

  • Jun Yin

    (Central China Normal University)

  • Guang-Fu Yang

    (Central China Normal University)

Abstract

Azo switches are widely employed as essential components in light-responsive systems. Here, we develop an azo-fluorescent switch that is visible light-responsive and its light-responsive processes can be monitored using fluorescence imaging. Visible light irradiation promotes isomerization, accompanied by changes in fluorescence that enable the process to be monitored through fluorescence imaging. Furthermore, we document that the nanocavity size of liposome encapsulated nanoparticles containing azo changes in the isomerization process and show that this change enables construction of a light-responsive nanoplatform for optically controlled release of antimycotics. Also, natural light activation of nanoparticles of the switch loaded with an antimycotic agent causes death of Rhizoctonia solani. The results show that these nanoparticles can double the holding period in comparison to small molecule antimycotics. The strategy used to design the imaging-guided light-controlled nano-antimycotic release system can be applicable to protocols for controlled delivery of a wide variety of drugs.

Suggested Citation

  • Yurou Huang & Xiaoyan Zeng & Xiaoxie Ma & Zibo Lin & Jiayue Sun & Wang Xiao & Sheng Hua Liu & Jun Yin & Guang-Fu Yang, 2024. "A visible light-activated azo-fluorescent switch for imaging-guided and light-controlled release of antimycotics," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52855-9
    DOI: 10.1038/s41467-024-52855-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-52855-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-52855-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Tommaso P. Fraccia & Nicolas Martin, 2023. "Non-enzymatic oligonucleotide ligation in coacervate protocells sustains compartment-content coupling," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52855-9. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.