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Striato-pallidal oscillatory connectivity correlates with symptom severity in dystonia patients

Author

Listed:
  • Roxanne Lofredi

    (Charité-Universitätsmedizin Berlin
    Berlin Institute of Health (BIH))

  • Lucia K. Feldmann

    (Charité-Universitätsmedizin Berlin)

  • Patricia Krause

    (Charité-Universitätsmedizin Berlin)

  • Ute Scheller

    (Charité-Universitätsmedizin Berlin
    Universität Göttingen)

  • Wolf-Julian Neumann

    (Charité-Universitätsmedizin Berlin
    Humboldt-Universität zu Berlin)

  • Joachim K. Krauss

    (Medizinische Hochschule Hannover)

  • Assel Saryyeva

    (Medizinische Hochschule Hannover)

  • Gerd-Helge Schneider

    (Charité-Universitätsmedizin Berlin)

  • Katharina Faust

    (Charité-Universitätsmedizin Berlin)

  • Tilmann Sander

    (Abbestraße 2)

  • Andrea A. Kühn

    (Charité-Universitätsmedizin Berlin
    Humboldt-Universität zu Berlin
    Charité-Universitätsmedizin Berlin
    German Center for Neurodegenerative Diseases)

Abstract

Dystonia is a hyperkinetic movement disorder that has been associated with an imbalance towards the direct pathway between striatum and internal pallidum, but the neuronal underpinnings of this abnormal basal ganglia pathway activity remain unknown. Here, we report invasive recordings from ten dystonia patients via deep brain stimulation electrodes that allow for parallel recordings of several basal ganglia nuclei, namely the striatum, external and internal pallidum, that all displayed activity in the low frequency band (3–12 Hz). In addition to a correlation with low-frequency activity in the internal pallidum (R = 0.88, P = 0.001), we demonstrate that dystonic symptoms correlate specifically with low-frequency coupling between striatum and internal pallidum (R = 0.75, P = 0.009). This points towards a pathophysiological role of the direct striato-pallidal pathway in dystonia that is conveyed via coupling in the enhanced low-frequency band. Our study provides a mechanistic insight into the pathophysiology of dystonia by revealing a link between symptom severity and frequency-specific coupling of distinct basal ganglia pathways.

Suggested Citation

  • Roxanne Lofredi & Lucia K. Feldmann & Patricia Krause & Ute Scheller & Wolf-Julian Neumann & Joachim K. Krauss & Assel Saryyeva & Gerd-Helge Schneider & Katharina Faust & Tilmann Sander & Andrea A. Kü, 2024. "Striato-pallidal oscillatory connectivity correlates with symptom severity in dystonia patients," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52814-4
    DOI: 10.1038/s41467-024-52814-4
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