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Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo

Author

Listed:
  • Christopher Thornton

    (Newcastle University)

  • Mariella Panagiotopoulou

    (Newcastle University)

  • Fahmida A. Chowdhury

    (UCL Queen Square Institute of Neurology)

  • Beate Diehl

    (UCL Queen Square Institute of Neurology)

  • John S. Duncan

    (UCL Queen Square Institute of Neurology)

  • Sarah J. Gascoigne

    (Newcastle University)

  • Guillermo Besne

    (Newcastle University)

  • Andrew W. McEvoy

    (UCL Queen Square Institute of Neurology)

  • Anna Miserocchi

    (UCL Queen Square Institute of Neurology)

  • Billy C. Smith

    (Newcastle University)

  • Jane Tisi

    (UCL Queen Square Institute of Neurology)

  • Peter N. Taylor

    (Newcastle University
    UCL Queen Square Institute of Neurology
    Newcastle University)

  • Yujiang Wang

    (Newcastle University
    UCL Queen Square Institute of Neurology
    Newcastle University)

Abstract

Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expression of biological rhythms in the brain. Here, we use the unique opportunity of long-term, continuous intracranially recorded EEG from 38 patients (totalling 6338 hours) to delineate circadian (daily) and ultradian (minute to hourly) rhythms in different brain regions. We show that functional circadian and ultradian rhythms are diminished in pathological tissue, independent of regional variations. We further demonstrate that these diminished rhythms are persistent in time, regardless of load or occurrence of pathological events. These findings provide evidence that brain pathology is functionally associated with persistently diminished chronobiological rhythms in vivo in humans, independent of regional variations or pathological events. Future work interacting with, and restoring, these modulatory chronobiological rhythms may allow for novel therapies.

Suggested Citation

  • Christopher Thornton & Mariella Panagiotopoulou & Fahmida A. Chowdhury & Beate Diehl & John S. Duncan & Sarah J. Gascoigne & Guillermo Besne & Andrew W. McEvoy & Anna Miserocchi & Billy C. Smith & Jan, 2024. "Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52769-6
    DOI: 10.1038/s41467-024-52769-6
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    References listed on IDEAS

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    1. Thomas G. Brooks & Nicholas F. Lahens & Gregory R. Grant & Yvette I. Sheline & Garret A. FitzGerald & Carsten Skarke, 2023. "Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
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