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Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

Author

Listed:
  • Jasper Panten

    (German Cancer Research Center (DKFZ)
    German Cancer Research Center (DKFZ))

  • Stefania Prete

    (German Cancer Research Center (DKFZ))

  • James P. Cleland

    (German Cancer Research Center (DKFZ)
    European Molecular Biology Laboratory (EMBL))

  • Lauren M. Saunders

    (German Cancer Research Center (DKFZ))

  • Job Riet

    (German Cancer Research Center (DKFZ)
    German Cancer Research Center (DKFZ))

  • Anja Schneider

    (German Cancer Research Center (DKFZ))

  • Paul Ginno

    (German Cancer Research Center (DKFZ))

  • Nina Schneider

    (German Cancer Research Center (DKFZ))

  • Marie-Luise Koch

    (German Cancer Research Center (DKFZ))

  • Xuqi Chen

    (University of California)

  • Moritz Gerstung

    (German Cancer Research Center (DKFZ))

  • Oliver Stegle

    (German Cancer Research Center (DKFZ)
    European Molecular Biology Laboratory (EMBL))

  • Arthur P. Arnold

    (University of California)

  • James M. A. Turner

    (The Francis Crick Institute)

  • Edith Heard

    (European Molecular Biology Laboratory (EMBL)
    Collège de France)

  • Duncan T. Odom

    (German Cancer Research Center (DKFZ))

Abstract

The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.

Suggested Citation

  • Jasper Panten & Stefania Prete & James P. Cleland & Lauren M. Saunders & Job Riet & Anja Schneider & Paul Ginno & Nina Schneider & Marie-Luise Koch & Xuqi Chen & Moritz Gerstung & Oliver Stegle & Arth, 2024. "Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52640-8
    DOI: 10.1038/s41467-024-52640-8
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