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Impact of pneumococcal conjugate vaccines on invasive pneumococcal disease-causing lineages among South African children

Author

Listed:
  • Cebile Lekhuleni

    (a division of the National Health Laboratory Service
    University of the Witwatersrand)

  • Kedibone Ndlangisa

    (a division of the National Health Laboratory Service)

  • Rebecca A. Gladstone

    (University of Oslo)

  • Sopio Chochua

    (Centers for Disease Control and Prevention)

  • Benjamin J. Metcalf

    (Centers for Disease Control and Prevention)

  • Yuan Li

    (Centers for Disease Control and Prevention)

  • Jackie Kleynhans

    (a division of the National Health Laboratory Service
    University of the Witwatersrand)

  • Linda Gouveia

    (a division of the National Health Laboratory Service)

  • Scott Hazelhurst

    (University of the Witwatersrand
    University of the Witwatersrand)

  • Ana D. S. Ferreira

    (Wellcome Genome Campus)

  • Happy Skosana

    (a division of the National Health Laboratory Service)

  • Sibongile Walaza

    (a division of the National Health Laboratory Service
    University of the Witwatersrand)

  • Vanessa Quan

    (A division of the National Health Laboratory Service)

  • Susan Meiring

    (A division of the National Health Laboratory Service)

  • Paulina A. Hawkins

    (Centers for Disease Control and Prevention)

  • Lesley McGee

    (Centers for Disease Control and Prevention)

  • Stephen D. Bentley

    (Wellcome Genome Campus)

  • Cheryl Cohen

    (a division of the National Health Laboratory Service
    University of the Witwatersrand)

  • Stephanie W. Lo

    (Wellcome Genome Campus
    University of Bath)

  • Anne Gottberg

    (a division of the National Health Laboratory Service
    University of the Witwatersrand
    University of Cape Town)

  • Mignon Plessis

    (a division of the National Health Laboratory Service
    University of the Witwatersrand)

Abstract

Invasive pneumococcal disease (IPD) due to non-vaccine serotypes after the introduction of pneumococcal conjugate vaccines (PCV) remains a global concern. This study used pathogen genomics to evaluate changes in invasive pneumococcal lineages before, during and after vaccine introduction in South Africa. We included genomes (N = 3104) of IPD isolates from individuals aged

Suggested Citation

  • Cebile Lekhuleni & Kedibone Ndlangisa & Rebecca A. Gladstone & Sopio Chochua & Benjamin J. Metcalf & Yuan Li & Jackie Kleynhans & Linda Gouveia & Scott Hazelhurst & Ana D. S. Ferreira & Happy Skosana , 2024. "Impact of pneumococcal conjugate vaccines on invasive pneumococcal disease-causing lineages among South African children," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52459-3
    DOI: 10.1038/s41467-024-52459-3
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