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Drug-induced change in transmitter identity is a shared mechanism generating cognitive deficits

Author

Listed:
  • Marta Pratelli

    (University of California San Diego
    University of California San Diego)

  • Anna M. Hakimi

    (University of California San Diego
    University of California San Diego)

  • Arth Thaker

    (University of California San Diego
    University of California San Diego)

  • Hyeonseok Jang

    (University of California San Diego)

  • Hui-quan Li

    (University of California San Diego
    University of California San Diego)

  • Swetha K. Godavarthi

    (University of California San Diego
    University of California San Diego)

  • Byung Kook Lim

    (University of California San Diego)

  • Nicholas C. Spitzer

    (University of California San Diego
    University of California San Diego)

Abstract

Cognitive deficits are long-lasting consequences of drug use, yet the convergent mechanism by which classes of drugs with different pharmacological properties cause similar deficits is unclear. We find that both phencyclidine and methamphetamine, despite differing in their targets in the brain, cause the same glutamatergic neurons in the medial prefrontal cortex of male mice to gain a GABAergic phenotype and decrease expression of their glutamatergic phenotype. Suppressing drug-induced gain of GABA with RNA-interference prevents appearance of memory deficits. Stimulation of dopaminergic neurons in the ventral tegmental area is necessary and sufficient to produce this gain of GABA. Drug-induced prefrontal hyperactivity drives this change in transmitter identity. Returning prefrontal activity to baseline, chemogenetically or with clozapine, reverses the change in transmitter phenotype and rescues the associated memory deficits. This work reveals a shared and reversible mechanism that regulates the appearance of cognitive deficits upon exposure to different drugs.

Suggested Citation

  • Marta Pratelli & Anna M. Hakimi & Arth Thaker & Hyeonseok Jang & Hui-quan Li & Swetha K. Godavarthi & Byung Kook Lim & Nicholas C. Spitzer, 2024. "Drug-induced change in transmitter identity is a shared mechanism generating cognitive deficits," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52451-x
    DOI: 10.1038/s41467-024-52451-x
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    References listed on IDEAS

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    1. Laura N. Borodinsky & Cory M. Root & Julia A. Cronin & Sharon B. Sann & Xiaonan Gu & Nicholas C. Spitzer, 2004. "Activity-dependent homeostatic specification of transmitter expression in embryonic neurons," Nature, Nature, vol. 429(6991), pages 523-530, June.
    2. Hui-quan Li & Nicholas C. Spitzer, 2020. "Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
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