Author
Listed:
- Min Yang
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Jing Ge
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Yu-Lian Liu
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Huan-Yu Wang
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Zhi-Han Wang
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Dan-Pei Li
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Rui He
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Yu-Yu Xie
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Hong-Yan Deng
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Xue-Min Peng
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Wen-She Wang
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Jia-Dai Liu
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Zeng-Zhe Zhu
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Xue-Feng Yu
(Huazhong University of Science and Technology
Branch of National Clinical Research Center for Metabolic Diseases)
- Pema Maretich
(Massachusetts Institute of Technology)
- Shingo Kajimura
(Beth Israel Deaconess Medical Center and Harvard Medical School, Howard Hughes Medical Institute)
- Ru-Ping Pan
(Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Yong Chen
(Huazhong University of Science and Technology
Huazhong University of Science and Technology
Huazhong University of Science and Technology
Branch of National Clinical Research Center for Metabolic Diseases)
Abstract
Beige fat activation involves a fuel switch to fatty acid oxidation following chronic cold adaptation. Mitochondrial acyl-CoA synthetase long-chain family member 1 (ACSL1) localizes in the mitochondria and plays a key role in fatty acid oxidation; however, the regulatory mechanism of the subcellular localization remains poorly understood. Here, we identify an endosomal trafficking component sortilin (encoded by Sort1) in adipose tissues that shows dynamic expression during beige fat activation and facilitates the translocation of ACSL1 from the mitochondria to the endolysosomal pathway for degradation. Depletion of sortilin in adipocytes results in an increase of mitochondrial ACSL1 and the activation of AMPK/PGC1α signaling, thereby activating beige fat and preventing high-fat diet (HFD)-induced obesity and insulin resistance. Collectively, our findings indicate that sortilin controls adipose tissue fatty acid oxidation by substrate fuel selection during beige fat activation and provides a potential targeted approach for the treatment of metabolic diseases.
Suggested Citation
Min Yang & Jing Ge & Yu-Lian Liu & Huan-Yu Wang & Zhi-Han Wang & Dan-Pei Li & Rui He & Yu-Yu Xie & Hong-Yan Deng & Xue-Min Peng & Wen-She Wang & Jia-Dai Liu & Zeng-Zhe Zhu & Xue-Feng Yu & Pema Maretic, 2024.
"Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice,"
Nature Communications, Nature, vol. 15(1), pages 1-17, December.
Handle:
RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52218-4
DOI: 10.1038/s41467-024-52218-4
Download full text from publisher
References listed on IDEAS
- Qian Wang & Dehai Li & Guangchao Cao & Qiping Shi & Jing Zhu & Mingyue Zhang & Hao Cheng & Qiong Wen & Hao Xu & Leqing Zhu & Hua Zhang & Rachel J. Perry & Olga Spadaro & Yunfan Yang & Shengqi He & Yon, 2021.
"IL-27 signalling promotes adipocyte thermogenesis and energy expenditure,"
Nature, Nature, vol. 600(7888), pages 314-318, December.
- Takeshi Yoneshiro & Qiang Wang & Kazuki Tajima & Mami Matsushita & Hiroko Maki & Kaori Igarashi & Zhipeng Dai & Phillip J. White & Robert W. McGarrah & Olga R. Ilkayeva & Yann Deleye & Yasuo Oguri & M, 2019.
"BCAA catabolism in brown fat controls energy homeostasis through SLC25A44,"
Nature, Nature, vol. 572(7771), pages 614-619, August.
Full references (including those not matched with items on IDEAS)
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.
- Donghua Hu & Min Tan & Dongliang Lu & Brian Kleiboeker & Xuejing Liu & Hongsuk Park & Alexxai V. Kravitz & Kooresh I. Shoghi & Yu-Hua Tseng & Babak Razani & Akihiro Ikeda & Irfan J. Lodhi, 2023.
"TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis,"
Nature Communications, Nature, vol. 14(1), pages 1-20, December.
- Xiaofan Yu & Gabrielle Benitez & Peter Tszki Wei & Sofia V. Krylova & Ziyi Song & Li Liu & Meifan Zhang & Alus M. Xiaoli & Henna Wei & Fenfen Chen & Simone Sidoli & Fajun Yang & Kosaku Shinoda & Jeffr, 2024.
"Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway,"
Nature Communications, Nature, vol. 15(1), pages 1-15, December.
- Clément Pontoizeau & Marcelo Simon-Sola & Clovis Gaborit & Vincent Nguyen & Irina Rotaru & Nolan Tual & Pasqualina Colella & Muriel Girard & Maria-Grazia Biferi & Jean-Baptiste Arnoux & Agnès Rötig & , 2022.
"Neonatal gene therapy achieves sustained disease rescue of maple syrup urine disease in mice,"
Nature Communications, Nature, vol. 13(1), pages 1-13, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52218-4. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.