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Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial

Author

Listed:
  • Simone Radavelli-Bagatini

    (Edith Cowan University)

  • Catherine P. Bondonno

    (Edith Cowan University
    University of Western Australia)

  • Jack Dalla Via

    (Edith Cowan University)

  • Marc Sim

    (Edith Cowan University
    University of Western Australia)

  • Abadi K. Gebre

    (Edith Cowan University)

  • Lauren C. Blekkenhorst

    (Edith Cowan University
    University of Western Australia)

  • Emma L. Connolly

    (Edith Cowan University)

  • Nicola P. Bondonno

    (Edith Cowan University
    Danish Cancer Institute)

  • John T. Schousboe

    (Park Nicollet Clinic and HealthPartners Institute
    University of Minnesota)

  • Richard J. Woodman

    (Flinders University)

  • Kun Zhu

    (University of Western Australia
    Sir Charles Gairdner Hospital)

  • Shelby Mullin

    (Sir Charles Gairdner Hospital)

  • Pawel Szulc

    (Hospices Civils de Lyon)

  • Ben Jackson

    (Telethon Kids Institute
    University of Western Australia)

  • James Dimmock

    (James Cook University)

  • Markus P. Schlaich

    (University of Western Australia
    Royal Perth Hospital Research Foundation
    Royal Perth Hospital
    Royal Perth Hospital)

  • Kay L. Cox

    (University of Western Australia)

  • Douglas P. Kiel

    (Hebrew SeniorLife
    Harvard Medical School)

  • Wai H. Lim

    (Edith Cowan University
    University of Western Australia
    Sir Charles Gairdner Hospital)

  • Mandy Stanley

    (Edith Cowan University)

  • Amanda Devine

    (Edith Cowan University)

  • Peter L. Thompson

    (University of Western Australia
    Sir Charles Gairdner Hospital)

  • Evan J. Williams

    (University of Newcastle)

  • Lisa G. Wood

    (University of Newcastle)

  • Moira Sim

    (Edith Cowan University)

  • Robin M. Daly

    (Deakin University)

  • Jonathan M. Hodgson

    (Edith Cowan University
    University of Western Australia)

  • Joshua R. Lewis

    (Edith Cowan University
    University of Western Australia
    The University of Sydney)

Abstract

Provision of non-invasive vascular imaging results to individuals has been shown to improve cardiovascular disease risk factor control: its impact on diet remains uncertain. In this two-arm, single-blind, parallel, 12-week randomized controlled trial, 240 participants, 57.5% females aged 60–80 y had abdominal aortic calcification and clinical assessments performed at a hospital clinic. Participants were randomized 1:1 to receive (intervention n = 121) or not (control n = 119) their calcification results. Both groups received educational resources on cardiovascular disease risk control and were unblinded to the intervention. Outcome measures were performed at baseline and 12 weeks. The primary outcomes of the study were changes in fruit and vegetable intake measures over 12 weeks assessed using plasma carotenoid concentrations (biomarkers of FV intake) and a food frequency questionnaire. Secondary outcomes included 12-week changes in other aspects of the diet, physical activity, body weight, blood pressure, heart rate, lipid profile, glucose concentrations, estimated cardiovascular disease risk score, and medication use. Between-group differences were tested using linear mixed-effects regression. There were no between-group differences in the primary outcomes at 12 weeks: plasma carotenoids (mean difference +0.03 µg/mL [95%CI −0.06, 0.13]) and fruit and vegetable intakes (+18 g/d [−37, 72]). However, the provision of calcification results led to between-group differences in serum total (−0.22 mmol/L [−0.41, −0.04]) and non-HDL (−0.19 mmol/L [−0.35, −0.03]) cholesterol, and estimated cardiovascular disease risk score (−0.24% [−0.47, −0.02]). No between-group differences were seen for other secondary outcomes. In this work, providing vascular imaging results did not improve diet but did improve some cardiovascular disease risk factors (Australian and New Zealand Clinical Trials Registry ACTRN12618001087246).

Suggested Citation

  • Simone Radavelli-Bagatini & Catherine P. Bondonno & Jack Dalla Via & Marc Sim & Abadi K. Gebre & Lauren C. Blekkenhorst & Emma L. Connolly & Nicola P. Bondonno & John T. Schousboe & Richard J. Woodman, 2024. "Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52172-1
    DOI: 10.1038/s41467-024-52172-1
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    1. Philip Ryan, 2000. "Random allocation of treatments balanced in blocks: update," Stata Technical Bulletin, StataCorp LP, vol. 9(54).
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