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Effect of single blastocyst-stage versus single cleavage-stage embryo transfer on cumulative live births in women with good prognosis undergoing in vitro fertilization: Multicenter Randomized Controlled Trial

Author

Listed:
  • Xiang Ma

    (the First Affiliated Hospital of Nanjing Medical University)

  • Jing Wang

    (the First Affiliated Hospital of Nanjing Medical University)

  • Yuhua Shi

    (Shandong University)

  • Jichun Tan

    (Shengjing Hospital of China Medical University
    Key Laboratory of Reproductive Dysfunction Disease and Fertility Remodeling of Liaoning Province)

  • Yichun Guan

    (the Third Affiliated Hospital of Zhengzhou University)

  • Yun Sun

    (Shanghai Jiao Tong University School of Medicine
    Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics)

  • Bo Zhang

    (Maternal and Child Health Hospital in Guang Xi)

  • Junli Zhao

    (General Hospital of Ningxia Medical University)

  • Jianqiao Liu

    (the Third Affiliated Hospital of Guangzhou Medical University
    the Third Affiliated Hospital, Guangzhou Medical University)

  • Yunxia Cao

    (the First Affiliated Hospital of Anhui Medical University
    NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University))

  • Hong Li

    (the Affiliated Suzhou Hospital of Nanjing Medical University)

  • Cuilian Zhang

    (Henan Provincial People’s Hospital)

  • Feng Chen

    (Nanjing Medical University)

  • Honggang Yi

    (Nanjing Medical University)

  • Ze Wang

    (Shandong University)

  • Xing Xin

    (Shengjing Hospital of China Medical University
    Key Laboratory of Reproductive Dysfunction Disease and Fertility Remodeling of Liaoning Province)

  • Pingping Kong

    (the Third Affiliated Hospital of Zhengzhou University)

  • Yao Lu

    (Shanghai Jiao Tong University School of Medicine
    Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics)

  • Ling Huang

    (Maternal and Child Health Hospital in Guang Xi)

  • Yingying Yuan

    (General Hospital of Ningxia Medical University)

  • Haiying Liu

    (the Third Affiliated Hospital of Guangzhou Medical University
    the Third Affiliated Hospital, Guangzhou Medical University)

  • Caihua Li

    (the First Affiliated Hospital of Anhui Medical University
    NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University))

  • Ben Willem J. Mol

    (Monash University
    Amsterdam University Medical Center
    Monash Health)

  • Zhibin Hu

    (the First Affiliated Hospital of Nanjing Medical University
    Nanjing Medical University
    Nanjing Medical University)

  • Heping Zhang

    (Yale University School of Public Health)

  • Zi-Jiang Chen

    (Shandong University
    Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics)

  • Jiayin Liu

    (the First Affiliated Hospital of Nanjing Medical University)

Abstract

In this multicenter, non-inferiority, randomized trial, we randomly assigned 992 women undergoing in-vitro fertilization (IVF) with a good prognosis (aged 20-40, ≥3 transferrable cleavage-stage embryos) to strategies of blastocyst-stage (n = 497) or cleavage-stage (n = 495) single embryo transfer. Primary outcome was cumulative live-birth rate after up to three transfers. Secondary outcomes were cumulative live-births after all embryo transfers within 1 year of randomization, pregnancy outcomes, obstetric-perinatal complications, and livebirths outcomes. Live-birth rates were 74.8% in blastocyst-stage group versus 66.3% in cleavage-stage group (relative risk 1.13, 95%CI:1.04-1.22; Pnon-inferiority 3 days. Among good prognosis women, a strategy of single blastocyst transfer increases cumulative live-birth rates over single cleavage-stage transfer. Blastocyst transfer resulted in higher preterm birth rates. This information should be used to counsel patients on their choice between cleavage-stage and blastocyst-stage transfer (NCT03152643, https://clinicaltrials.gov/study/NCT03152643 ).

Suggested Citation

  • Xiang Ma & Jing Wang & Yuhua Shi & Jichun Tan & Yichun Guan & Yun Sun & Bo Zhang & Junli Zhao & Jianqiao Liu & Yunxia Cao & Hong Li & Cuilian Zhang & Feng Chen & Honggang Yi & Ze Wang & Xing Xin & Pin, 2024. "Effect of single blastocyst-stage versus single cleavage-stage embryo transfer on cumulative live births in women with good prognosis undergoing in vitro fertilization: Multicenter Randomized Controll," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52008-y
    DOI: 10.1038/s41467-024-52008-y
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