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Tissue-scale in vitro epithelial wrinkling and wrinkle-to-fold transition

Author

Listed:
  • Jaeseung Youn

    (Pohang University of Science and Technology (POSTECH))

  • Dohui Kim

    (Pohang University of Science and Technology (POSTECH))

  • Hyunsu Kwak

    (Pohang University of Science and Technology (POSTECH))

  • Anna Lee

    (Pohang University of Science and Technology (POSTECH))

  • Dong Sung Kim

    (Pohang University of Science and Technology (POSTECH)
    Pohang University of Science and Technology (POSTECH)
    Pohang University of Science and Technology (POSTECH)
    Yonsei University)

Abstract

Although epithelial folding is commonly studied using in vivo animal models, such models exhibit critical limitations in terms of real-time observation and independent control of experimental parameters. Here, we develop a tissue-scale in vitro epithelial bilayer folding model that incorporates an epithelium and extracellular matrix (ECM) hydrogel, thereby emulating various folding structures found in in vivo epithelial tissue. Beyond mere folding, our in vitro model realizes a hierarchical transition in the epithelial bilayer, shifting from periodic wrinkles to a single deep fold under compression. Experimental and theoretical investigations of the in vitro model imply that both the strain-stiffening of epithelium and the poroelasticity of ECM influence the folded structures of epithelial tissue. The proposed in vitro model will aid in investigating the underlying mechanism of tissue-scale in vivo epithelial folding relevant to developmental biology and tissue engineering.

Suggested Citation

  • Jaeseung Youn & Dohui Kim & Hyunsu Kwak & Anna Lee & Dong Sung Kim, 2024. "Tissue-scale in vitro epithelial wrinkling and wrinkle-to-fold transition," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51437-z
    DOI: 10.1038/s41467-024-51437-z
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    References listed on IDEAS

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    1. Yu-Chiun Wang & Zia Khan & Matthias Kaschube & Eric F. Wieschaus, 2012. "Differential positioning of adherens junctions is associated with initiation of epithelial folding," Nature, Nature, vol. 484(7394), pages 390-393, April.
    2. B. Buchmann & L. K. Engelbrecht & P. Fernandez & F. P. Hutterer & M. K. Raich & C. H. Scheel & A. R. Bausch, 2021. "Mechanical plasticity of collagen directs branch elongation in human mammary gland organoids," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
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