IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-51372-z.html
   My bibliography  Save this article

Modelling variability and heterogeneity of EMT scenarios highlights nuclear positioning and protrusions as main drivers of extrusion

Author

Listed:
  • Steffen Plunder

    (UPS
    University of Vienna
    Sakyo-ku)

  • Cathy Danesin

    (UPS)

  • Bruno Glise

    (UPS)

  • Marina A. Ferreira

    (University of Coimbra)

  • Sara Merino-Aceituno

    (University of Vienna)

  • Eric Theveneau

    (UPS)

Abstract

Epithelial-Mesenchymal Transition (EMT) is a key process in physiological and pathological settings. EMT is often presented as a linear sequence with (i) disassembly of cell-cell junctions, (ii) loss of epithelial polarity and (iii) reorganization of the cytoskeleton leading to basal extrusion from the epithelium. Once out, cells can adopt a migratory phenotype with a front-rear polarity. While this sequence can occur, in vivo observations have challenged it. It is now accepted that multiple EMT scenarios coexist in heterogeneous cell populations. However, the relative importance of each step as well as that of variability and heterogeneity on the efficiency of cell extrusion has not been assessed. Here we used computational modelling to simulate multiple EMT-like scenarios and confronted these data to the EMT of neural crest cells. Overall, our data point to a key role of nuclear positioning and protrusive activity to generate timely basal extrusion.

Suggested Citation

  • Steffen Plunder & Cathy Danesin & Bruno Glise & Marina A. Ferreira & Sara Merino-Aceituno & Eric Theveneau, 2024. "Modelling variability and heterogeneity of EMT scenarios highlights nuclear positioning and protrusions as main drivers of extrusion," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51372-z
    DOI: 10.1038/s41467-024-51372-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-51372-z
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-51372-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Toni Celià-Terrassa & Caleb Bastian & Daniel D. Liu & Brian Ell & Nicole M. Aiello & Yong Wei & Jose Zamalloa & Andres M. Blanco & Xiang Hang & Dmitriy Kunisky & Wenyang Li & Elizabeth D. Williams & H, 2018. "Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    2. Antti Lignell & Laura Kerosuo & Sebastian J. Streichan & Long Cai & Marianne E. Bronner, 2017. "Identification of a neural crest stem cell niche by Spatial Genomic Analysis," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    3. Ievgenia Pastushenko & Audrey Brisebarre & Alejandro Sifrim & Marco Fioramonti & Tatiana Revenco & Soufiane Boumahdi & Alexandra Van Keymeulen & Daniel Brown & Virginie Moers & Sophie Lemaire & Sarah , 2018. "Identification of the tumour transition states occurring during EMT," Nature, Nature, vol. 556(7702), pages 463-468, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. C. Megan Young & Laurent Beziaud & Pierre Dessen & Angela Madurga Alonso & Albert Santamaria-Martínez & Joerg Huelsken, 2023. "Metabolic dependencies of metastasis-initiating cells in female breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Patrick Aouad & Yueyun Zhang & Fabio Martino & Céline Stibolt & Simak Ali & Giovanna Ambrosini & Sendurai A. Mani & Kelly Maggs & Hazel M. Quinn & George Sflomos & Cathrin Brisken, 2022. "Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Guidantonio Malagoli Tagliazucchi & Anna J. Wiecek & Eloise Withnell & Maria Secrier, 2023. "Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Helen F. McCreery & Georgina Gemayel & Ana Isabel Pais & Simon Garnier & Radhika Nagpal, 2022. "Hysteresis stabilizes dynamic control of self-assembled army ant constructions," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Laura Lorenzo-Sanz & Marta Lopez-Cerda & Victoria da Silva-Diz & Marta H. Artés & Sandra Llop & Rosa M. Penin & Josep Oriol Bermejo & Eva Gonzalez-Suarez & Manel Esteller & Francesc Viñals & Enrique E, 2024. "Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    6. Peter Bailey & Rachel A. Ridgway & Patrizia Cammareri & Mairi Treanor-Taylor & Ulla-Maja Bailey & Christina Schoenherr & Max Bone & Daniel Schreyer & Karin Purdie & Jason Thomson & William Rickaby & R, 2023. "Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    7. Yael Aylon & Noa Furth & Giuseppe Mallel & Gilgi Friedlander & Nishanth Belugali Nataraj & Meng Dong & Ori Hassin & Rawan Zoabi & Benjamin Cohen & Vanessa Drendel & Tomer Meir Salame & Saptaparna Mukh, 2022. "Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    8. Cécile Thirant & Agathe Peltier & Simon Durand & Amira Kramdi & Caroline Louis-Brennetot & Cécile Pierre-Eugène & Margot Gautier & Ana Costa & Amandine Grelier & Sakina Zaïdi & Nadège Gruel & Irène Ji, 2023. "Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    9. Nastaran Mohammadi Ghahhari & Magdalena K. Sznurkowska & Nicolas Hulo & Lilia Bernasconi & Nicola Aceto & Didier Picard, 2022. "Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    10. Ceren Pajanoja & Jenny Hsin & Bradley Olinger & Andrew Schiffmacher & Rita Yazejian & Shaun Abrams & Arvydas Dapkunas & Zarin Zainul & Andrew D. Doyle & Daniel Martin & Laura Kerosuo, 2023. "Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    11. Mrinmoy Mukherjee & Herbert Levine, 2021. "Cluster size distribution of cells disseminating from a primary tumor," PLOS Computational Biology, Public Library of Science, vol. 17(11), pages 1-23, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51372-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.