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Hippo signaling pathway regulates Ebola virus transcription and egress

Author

Listed:
  • Jingjing Liang

    (University of Pennsylvania)

  • Marija A. Djurkovic

    (Texas Biomedical Research Institute)

  • Carson G. Leavitt

    (Texas Biomedical Research Institute)

  • Olena Shtanko

    (Texas Biomedical Research Institute)

  • Ronald N. Harty

    (University of Pennsylvania)

Abstract

Filovirus-host interactions play important roles in all stages of the virus lifecycle. Here, we identify LATS1/2 kinases and YAP, key components of the Hippo pathway, as critical regulators of EBOV transcription and egress. Specifically, we find that when YAP is phosphorylated by LATS1/2, it localizes to the cytoplasm (Hippo “ON”) where it sequesters VP40 to prevent egress. In contrast, when the Hippo pathway is “OFF”, unphosphorylated YAP translocates to the nucleus where it transcriptionally activates host genes and promotes viral egress. Our data reveal that LATS2 indirectly modulates filoviral VP40-mediated egress through phosphorylation of AMOTp130, a positive regulator of viral egress, but more surprisingly that LATS1/2 kinases directly modulate EBOV transcription by phosphorylating VP30, an essential regulator of viral transcription. In sum, our findings highlight the potential to exploit the Hippo pathway/filovirus axis for the development of host-oriented countermeasures targeting EBOV and related filoviruses.

Suggested Citation

  • Jingjing Liang & Marija A. Djurkovic & Carson G. Leavitt & Olena Shtanko & Ronald N. Harty, 2024. "Hippo signaling pathway regulates Ebola virus transcription and egress," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51356-z
    DOI: 10.1038/s41467-024-51356-z
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    References listed on IDEAS

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    1. Fengyuan Tang & Ruize Gao & Beena Jeevan-Raj & Christof B. Wyss & Ravi K. R. Kalathur & Salvatore Piscuoglio & Charlotte K. Y. Ng & Sravanth K. Hindupur & Sandro Nuciforo & Eva Dazert & Thomas Bock & , 2019. "LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    2. Zhipeng Meng & Toshiro Moroishi & Violaine Mottier-Pavie & Steven W. Plouffe & Carsten G. Hansen & Audrey W. Hong & Hyun Woo Park & Jung-Soon Mo & Wenqi Lu & Shicong Lu & Fabian Flores & Fa-Xing Yu & , 2015. "MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway," Nature Communications, Nature, vol. 6(1), pages 1-13, December.
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