IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-51248-2.html
   My bibliography  Save this article

Minimally invasive soft tissue repair using shrunken scaffolds

Author

Listed:
  • Mingjun Xie

    (School of Mechanical Engineering, Zhejiang University
    School of Mechanical Engineering, Zhejiang University
    Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College)

  • Shengxi Jin

    (School of Medicine, Zhejiang University)

  • Kang Yu

    (School of Mechanical Engineering, Zhejiang University
    School of Mechanical Engineering, Zhejiang University)

  • Hui Lin

    (School of Medicine, Zhejiang University
    Zhejiang University)

  • Yong He

    (School of Mechanical Engineering, Zhejiang University
    School of Mechanical Engineering, Zhejiang University)

Abstract

The minimally invasive injection of tissue engineering scaffolds is of interest as it requires a smaller incision and quickens recovery. However, the engineering of scaffolds capable of injection remains a challenge. Here, we report on a shrunken scaffold inspired by the shrinking of puffed food in a humid environment. A scaffold is freeze-dried to remove water then placed in a humid atmosphere. The humidity causes the dry scaffold to shrink by up to 90%. In addition, the humidity treatment reduces the scaffolds modulus minimizing the foreign body response after implantation. The scaffolds can rapidly swell into their original size and shape after application. A tool for the delivery of the minimally invasive scaffolds is developed and we demonstrate the potential for minimally invasive delivery using this shrinking technique.

Suggested Citation

  • Mingjun Xie & Shengxi Jin & Kang Yu & Hui Lin & Yong He, 2024. "Minimally invasive soft tissue repair using shrunken scaffolds," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51248-2
    DOI: 10.1038/s41467-024-51248-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-51248-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-51248-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51248-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.