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Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial

Author

Listed:
  • Yumin Zhou

    (Guangzhou Medical University
    Bio-land)

  • Fan Wu

    (Guangzhou Medical University
    Bio-land)

  • Zhe Shi

    (Huizhou First Hospital)

  • Jie Cao

    (Tianjin Medical University General Hospital)

  • Jia Tian

    (The Second People’s Hospital of Hunan Province)

  • Weimin Yao

    (The Second Affiliated Hospital of Guangdong Medical University)

  • Liping Wei

    (The Third Affiliated Hospital of Guangzhou Medical University)

  • Fenglei Li

    (Liwan Central Hospital of Guangzhou)

  • Shan Cai

    (The Second Xiangya Hospital of Central South University)

  • Yao Shen

    (Fudan University Pudong Medical Center)

  • Zanfeng Wang

    (The First Hospital of China Medical University)

  • Huilan Zhang

    (Huazhong University of Science and Technology)

  • Yanfan Chen

    (The First Hospital of Wenzhou Medical University)

  • Yingyun Fu

    (Shenzhen People’s Hospital)

  • Zhiyi He

    (The First Hospital of Guangxi Medical University)

  • Chun Chang

    (Peking University Third Hospital)

  • Yongliang Jiang

    (Hunan Provincial People’s Hospital)

  • Shujing Chen

    (Fudan University)

  • Changli Yang

    (Wengyuan County People’s Hospital)

  • Shuqing Yu

    (Lianping County Hospital of Traditional Chinese Medicine)

  • Heshen Tian

    (Guangzhou Medical University)

  • Qijian Cheng

    (Shanghai Jiao Tong University School of Medicine)

  • Ziwen Zhao

    (Guangzhou First People’s Hospital)

  • Yinghua Ying

    (The Second Affiliated Hospital of Zhejiang University School of Medicine)

  • Yong Zhou

    (Zhejiang University School of Medicine)

  • Shengming Liu

    (The First Affiliated Hospital of Jinan University)

  • Zhishan Deng

    (Guangzhou Medical University)

  • Peiyu Huang

    (Guangzhou Medical University)

  • Yunzhen Zhang

    (Huizhou First Hospital)

  • Xiangwen Luo

    (Lianping County Hospital of Traditional Chinese Medicine)

  • Haiyan Zhao

    (Tianjin Medical University General Hospital)

  • Jianping Gui

    (The Second People’s Hospital of Hunan Province)

  • Weiguang Lai

    (The Affiliated Hospital of Guangdong Medical University)

  • Guoping Hu

    (The Third Affiliated Hospital of Guangzhou Medical University)

  • Cong Liu

    (The Second Xiangya Hospital of Central South University)

  • Ling Su

    (Fudan University Pudong Medical Center)

  • Zhiguang Liu

    (Hunan Provincial People’s Hospital)

  • Jianhui Huang

    (Lianping County Hospital of Traditional Chinese Medicine)

  • Dongxing Zhao

    (Guangzhou Medical University)

  • Nanshan Zhong

    (Guangzhou Medical University
    Bio-land)

  • Pixin Ran

    (Guangzhou Medical University
    Bio-land)

Abstract

Evidence for the treatment of patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) is limited. The efficacy of N-acetylcysteine (an antioxidant and mucolytic agent) for patients with mild-to-moderate COPD is uncertain. In this multicentre, randomised, double-blind, placebo-controlled trial, we randomly assigned 968 patients with mild-to-moderate COPD to treatment with N-acetylcysteine (600 mg, twice daily) or matched placebo for two years. Eligible participants were 40-80 years of age and had mild-to-moderate COPD (forced expiratory volume in 1 second [FEV1] to forced vital capacity ratio

Suggested Citation

  • Yumin Zhou & Fan Wu & Zhe Shi & Jie Cao & Jia Tian & Weimin Yao & Liping Wei & Fenglei Li & Shan Cai & Yao Shen & Zanfeng Wang & Huilan Zhang & Yanfan Chen & Yingyun Fu & Zhiyi He & Chun Chang & Yongl, 2024. "Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51079-1
    DOI: 10.1038/s41467-024-51079-1
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    References listed on IDEAS

    as
    1. Peter Calverley & Paola Rogliani & Alberto Papi, 2021. "Safety of N-Acetylcysteine at High Doses in Chronic Respiratory Diseases: A Review," Drug Safety, Springer, vol. 44(3), pages 273-290, March.
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