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Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges

Author

Listed:
  • Fiona Howroyd

    (University Hospitals Birmingham NHS Foundation Trust
    The University of Birmingham, Edgbaston)

  • Cyril Chacko

    (The Royal Wolverhampton NHS Trust
    Royal Wolverhampton Hospital and University of Wolverhampton)

  • Andrew MacDuff

    (The Royal Wolverhampton NHS Trust
    Royal Wolverhampton Hospital and University of Wolverhampton)

  • Nandan Gautam

    (Mindelsohn Way)

  • Brian Pouchet

    (Mindelsohn Way)

  • Bill Tunnicliffe

    (Mindelsohn Way)

  • Jonathan Weblin

    (University Hospitals Birmingham NHS Foundation Trust)

  • Fang Gao-Smith

    (The University of Birmingham, Edgbaston)

  • Zubair Ahmed

    (The University of Birmingham, Edgbaston)

  • Niharika A. Duggal

    (The University of Birmingham, Edgbaston)

  • Tonny Veenith

    (The Royal Wolverhampton NHS Trust
    Royal Wolverhampton Hospital and University of Wolverhampton)

Abstract

Ventilator-associated pneumonia (VAP) affects up to 20% of critically ill patients and induces significant antibiotic prescription pressure, accounting for half of all antibiotic use in the ICU. VAP significantly increases hospital length of stay and healthcare costs yet is also associated with long-term morbidity and mortality. The diagnosis of VAP continues to present challenges and pitfalls for the currently available clinical, radiological and microbiological diagnostic armamentarium. Biomarkers and artificial intelligence offer an innovative potential direction for ongoing future research. In this Review, we summarise the pathobiological heterogeneity and diagnostic challenges associated with VAP.

Suggested Citation

  • Fiona Howroyd & Cyril Chacko & Andrew MacDuff & Nandan Gautam & Brian Pouchet & Bill Tunnicliffe & Jonathan Weblin & Fang Gao-Smith & Zubair Ahmed & Niharika A. Duggal & Tonny Veenith, 2024. "Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50805-z
    DOI: 10.1038/s41467-024-50805-z
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