IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-50741-y.html
   My bibliography  Save this article

Ultrasound-responsive theranostic platform for the timely monitoring and efficient thrombolysis in thrombi of tPA resistance

Author

Listed:
  • Lin Lin

    (Third Military Medical University
    Chongqing University
    Jinfeng Laboratory)

  • Zhaojing Ba

    (Third Military Medical University)

  • Hao Tian

    (Third Military Medical University)

  • Haoxiang Qin

    (Third Military Medical University)

  • Xi Chen

    (Third Military Medical University)

  • Xin Zhou

    (Third Military Medical University)

  • Shanlan Zhao

    (Third Military Medical University)

  • Lang Li

    (Third Military Medical University)

  • Fangchao Xue

    (Third Military Medical University)

  • Hong Li

    (Third Military Medical University)

  • Lang He

    (Third Military Medical University
    Jinfeng Laboratory)

  • Xiaochen Li

    (Third Military Medical University)

  • Jiahui Du

    (Third Military Medical University)

  • Zhenhua Zhou

    (Third Military Medical University)

  • Wen Zeng

    (Third Military Medical University
    Jinfeng Laboratory
    Third Military Medical University)

Abstract

There is no effective and noninvasive solution for thrombolysis because the mechanism by which certain thrombi become tissue plasminogen activator (tPA)-resistant remains obscure. Endovascular thrombectomy is the last option for these tPA-resistant thrombi, thus a new noninvasive strategy is urgently needed. Through an examination of thrombi retrieved from stroke patients, we found that neutrophil extracellular traps (NETs), ε-(γ-glutamyl) lysine isopeptide bonds and fibrin scaffolds jointly comprise the key chain in tPA resistance. A theranostic platform is designed to combine sonodynamic and mechanical thrombolysis under the guidance of ultrasonic imaging. Breakdown of the key chain leads to a recanalization rate of more than 90% in male rat tPA-resistant occlusion model. Vascular reconstruction is observed one month after recanalization, during which there was no thrombosis recurrence. The system also demonstrates noninvasive theranostic capabilities in managing pigs’ long thrombi (>8 mm) and in revascularizing thrombosis-susceptible tissue-engineered vascular grafts, indicating its potential for clinical application. Overall, this noninvasive theranostic platform provides a new strategy for treating tPA-resistant thrombi.

Suggested Citation

  • Lin Lin & Zhaojing Ba & Hao Tian & Haoxiang Qin & Xi Chen & Xin Zhou & Shanlan Zhao & Lang Li & Fangchao Xue & Hong Li & Lang He & Xiaochen Li & Jiahui Du & Zhenhua Zhou & Wen Zeng, 2024. "Ultrasound-responsive theranostic platform for the timely monitoring and efficient thrombolysis in thrombi of tPA resistance," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50741-y
    DOI: 10.1038/s41467-024-50741-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-50741-y
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-50741-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Elzbieta Kolaczkowska & Craig N. Jenne & Bas G. J. Surewaard & Ajitha Thanabalasuriar & Woo-Yong Lee & Maria-Jesus Sanz & Kerri Mowen & Ghislain Opdenakker & Paul Kubes, 2015. "Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature," Nature Communications, Nature, vol. 6(1), pages 1-13, May.
    2. Lijing Kang & Huilin Yu & Xing Yang & Yuanbo Zhu & Xiaofei Bai & Ranran Wang & Yongliang Cao & Haochen Xu & Haiyu Luo & Lu Lu & Mei-Juan Shi & Yujing Tian & Wenying Fan & Bing-Qiao Zhao, 2020. "Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yafeng Li & Jessica S. Hook & Qing Ding & Xue Xiao & Stephen S. Chung & Marcel Mettlen & Lin Xu & Jessica G. Moreland & Michalis Agathocleous, 2023. "Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50741-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.