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Towards enhanced functionality of vagus neuroprostheses through in silico optimized stimulation

Author

Listed:
  • Federico Ciotti

    (ETH Zürich)

  • Robert John

    (ETH Zürich)

  • Natalija Katic Secerovic

    (ETH Zürich
    University of Belgrade)

  • Noemi Gozzi

    (ETH Zürich)

  • Andrea Cimolato

    (ETH Zürich)

  • Naveen Jayaprakash

    (Northwell Health
    Feinstein Institutes for Medical Research)

  • Weiguo Song

    (Northwell Health
    Feinstein Institutes for Medical Research)

  • Viktor Toth

    (Northwell Health
    Feinstein Institutes for Medical Research)

  • Theodoros Zanos

    (Northwell Health
    Feinstein Institutes for Medical Research
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
    Elmezzi Graduate School of Molecular Medicine)

  • Stavros Zanos

    (Northwell Health
    Feinstein Institutes for Medical Research
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
    Elmezzi Graduate School of Molecular Medicine)

  • Stanisa Raspopovic

    (ETH Zürich
    Medical University of Vienna)

Abstract

Bioelectronic therapies modulating the vagus nerve are promising for cardiovascular, inflammatory, and mental disorders. Clinical applications are however limited by side-effects such as breathing obstruction and headache caused by non-specific stimulation. To design selective and functional stimulation, we engineered VaStim, a realistic and efficient in-silico model. We developed a protocol to personalize VaStim in-vivo using simple muscle responses, successfully reproducing experimental observations, by combining models with trials conducted on five pigs. Through optimized algorithms, VaStim simulated the complete fiber population in minutes, including often omitted unmyelinated fibers which constitute 80% of the nerve. The model suggested that all Aα-fibers across the nerve affect laryngeal muscle, while heart rate changes were caused by B-efferents in specific fascicles. It predicted that tripolar paradigms could reduce laryngeal activity by 70% compared to typically used protocols. VaStim may serve as a model for developing neuromodulation therapies by maximizing efficacy and specificity, reducing animal experimentation.

Suggested Citation

  • Federico Ciotti & Robert John & Natalija Katic Secerovic & Noemi Gozzi & Andrea Cimolato & Naveen Jayaprakash & Weiguo Song & Viktor Toth & Theodoros Zanos & Stavros Zanos & Stanisa Raspopovic, 2024. "Towards enhanced functionality of vagus neuroprostheses through in silico optimized stimulation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50523-6
    DOI: 10.1038/s41467-024-50523-6
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    References listed on IDEAS

    as
    1. Jesse E Bucksot & Andrew J Wells & Kimiya C Rahebi & Vishnoukumaar Sivaji & Mario Romero-Ortega & Michael P Kilgard & Robert L Rennaker II & Seth A Hays, 2019. "Flat electrode contacts for vagus nerve stimulation," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-22, November.
    2. Eric D Musselman & Jake E Cariello & Warren M Grill & Nicole A Pelot, 2021. "ASCENT (Automated Simulations to Characterize Electrical Nerve Thresholds): A pipeline for sample-specific computational modeling of electrical stimulation of peripheral nerves," PLOS Computational Biology, Public Library of Science, vol. 17(9), pages 1-19, September.
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