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Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm

Author

Listed:
  • Yuchao Jiang

    (Fudan University
    Ministry of Education)

  • Cheng Luo

    (University of Electronic Science and Technology of China
    University of Electronic Science and Technology of China
    Chinese Academy of Medical Sciences)

  • Jijun Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Lena Palaniyappan

    (McGill University)

  • Xiao Chang

    (Fudan University
    Ministry of Education)

  • Shitong Xiang

    (Fudan University
    Ministry of Education)

  • Jie Zhang

    (Fudan University
    Ministry of Education)

  • Mingjun Duan

    (University of Electronic Science and Technology of China)

  • Huan Huang

    (University of Electronic Science and Technology of China)

  • Christian Gaser

    (Jena University Hospital
    Jena University Hospital
    Site Jena-Magdeburg-Halle)

  • Kiyotaka Nemoto

    (University of Tsukuba)

  • Kenichiro Miura

    (National Institute of Mental Health, National Center of Neurology and Psychiatry)

  • Ryota Hashimoto

    (National Institute of Mental Health, National Center of Neurology and Psychiatry)

  • Lars T. Westlye

    (University of Oslo
    Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
    University of Oslo and Oslo University Hospital)

  • Genevieve Richard

    (University of Oslo
    Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
    University of Oslo and Oslo University Hospital)

  • Sara Fernandez-Cabello

    (University of Oslo
    Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
    University of Oslo and Oslo University Hospital)

  • Nadine Parker

    (Oslo University Hospital & Institute of Clinical Medicine, University of Oslo)

  • Ole A. Andreassen

    (Oslo University Hospital & Institute of Clinical Medicine, University of Oslo)

  • Tilo Kircher

    (Philipps Universität Marburg)

  • Igor Nenadić

    (Philipps Universität Marburg)

  • Frederike Stein

    (Philipps Universität Marburg)

  • Florian Thomas-Odenthal

    (Philipps Universität Marburg)

  • Lea Teutenberg

    (Philipps Universität Marburg)

  • Paula Usemann

    (Philipps Universität Marburg)

  • Udo Dannlowski

    (University of Münster)

  • Tim Hahn

    (University of Münster)

  • Dominik Grotegerd

    (University of Münster)

  • Susanne Meinert

    (University of Münster
    University of Münster)

  • Rebekka Lencer

    (University of Münster
    Lübeck University
    University of Münster)

  • Yingying Tang

    (Shanghai Jiao Tong University School of Medicine)

  • Tianhong Zhang

    (Shanghai Jiao Tong University School of Medicine)

  • Chunbo Li

    (Shanghai Jiao Tong University School of Medicine)

  • Weihua Yue

    (Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)
    Chinese Institute for Brain Research
    Peking University)

  • Yuyanan Zhang

    (Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital))

  • Xin Yu

    (Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital))

  • Enpeng Zhou

    (Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital))

  • Ching-Po Lin

    (National Yang Ming Chiao Tung University)

  • Shih-Jen Tsai

    (Taipei Veterans General Hospital)

  • Amanda L. Rodrigue

    (Boston Children’s Hospital, Harvard Medical School)

  • David Glahn

    (Boston Children’s Hospital, Harvard Medical School)

  • Godfrey Pearlson

    (Institute of Living)

  • John Blangero

    (University of Texas of the Rio Grande Valley)

  • Andriana Karuk

    (FIDMAG Germanes Hospitalàries Research Foundation
    Instituto de Salud Carlos III)

  • Edith Pomarol-Clotet

    (FIDMAG Germanes Hospitalàries Research Foundation
    Instituto de Salud Carlos III)

  • Raymond Salvador

    (FIDMAG Germanes Hospitalàries Research Foundation
    Instituto de Salud Carlos III)

  • Paola Fuentes-Claramonte

    (FIDMAG Germanes Hospitalàries Research Foundation
    Instituto de Salud Carlos III)

  • María Ángeles Garcia-León

    (FIDMAG Germanes Hospitalàries Research Foundation
    Instituto de Salud Carlos III)

  • Gianfranco Spalletta

    (IRCCS Santa Lucia Foundation)

  • Fabrizio Piras

    (IRCCS Santa Lucia Foundation)

  • Daniela Vecchio

    (IRCCS Santa Lucia Foundation)

  • Nerisa Banaj

    (IRCCS Santa Lucia Foundation)

  • Jingliang Cheng

    (The First Affiliated Hospital of Zhengzhou University)

  • Zhening Liu

    (The Second Xiangya Hospital of Central South University)

  • Jie Yang

    (The Second Xiangya Hospital of Central South University)

  • Ali Saffet Gonul

    (SoCAT Lab)

  • Ozgul Uslu

    (Ege University Institute of Health Sciences Department of Neuroscience)

  • Birce Begum Burhanoglu

    (Ege University Institute of Health Sciences Department of Neuroscience)

  • Aslihan Uyar Demir

    (SoCAT Lab)

  • Kelly Rootes-Murdy

    (Emory University])

  • Vince D. Calhoun

    (Emory University])

  • Kang Sim

    (Institute of Mental Health
    National University of Singapore
    Nanyang Technological University)

  • Melissa Green

    (University of New South Wales)

  • Yann Quidé

    (University of New South Wales)

  • Young Chul Chung

    (Jeonbuk National University Hospital
    Jeonbuk National University, Medical School
    Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital)

  • Woo-Sung Kim

    (Jeonbuk National University Hospital
    Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital)

  • Scott R. Sponheim

    (University of Minnesota
    University of Minnesota
    University of Minnesota)

  • Caroline Demro

    (University of Minnesota)

  • Ian S. Ramsay

    (University of Minnesota)

  • Felice Iasevoli

    (University “Federico II”)

  • Andrea Bartolomeis

    (University “Federico II”)

  • Annarita Barone

    (University “Federico II”)

  • Mariateresa Ciccarelli

    (University “Federico II”)

  • Arturo Brunetti

    (University “Federico II”)

  • Sirio Cocozza

    (University “Federico II”)

  • Giuseppe Pontillo

    (University “Federico II”)

  • Mario Tranfa

    (University “Federico II”)

  • Min Tae M. Park

    (University of Toronto
    Centre for Addiction and Mental Health)

  • Matthias Kirschner

    (University Hospitals of Geneva
    Psychiatric Hospital University of Zurich)

  • Foivos Georgiadis

    (Psychiatric Hospital University of Zurich)

  • Stefan Kaiser

    (University Hospitals of Geneva)

  • Tamsyn E. Rheenen

    (University of Melbourne
    Swinburne University)

  • Susan L. Rossell

    (Swinburne University)

  • Matthew Hughes

    (Swinburne University)

  • William Woods

    (Swinburne University)

  • Sean P. Carruthers

    (Swinburne University)

  • Philip Sumner

    (Swinburne University)

  • Elysha Ringin

    (National Institute of Mental Health)

  • Filip Spaniel

    (National Institute of Mental Health)

  • Antonin Skoch

    (National Institute of Mental Health
    Institute for Clinical and Experimental Medicine)

  • David Tomecek

    (National Institute of Mental Health
    Czech Academy of Sciences
    Czech Technical University in Prague)

  • Philipp Homan

    (University of Zurich
    University of Zurich & Swiss Federal Institute of Technology Zurich)

  • Stephanie Homan

    (Psychiatric University Hospital Zurich
    University of Zurich)

  • Wolfgang Omlor

    (University of Zurich)

  • Giacomo Cecere

    (University of Zurich)

  • Dana D. Nguyen

    (University of California Irvine)

  • Adrian Preda

    (University of California Irvine)

  • Sophia I. Thomopoulos

    (University of Southern California)

  • Neda Jahanshad

    (University of Southern California)

  • Long-Biao Cui

    (Fourth Military Medical University)

  • Dezhong Yao

    (University of Electronic Science and Technology of China
    University of Electronic Science and Technology of China
    Chinese Academy of Medical Sciences)

  • Paul M. Thompson

    (University of Southern California)

  • Jessica A. Turner

    (Ohio State Wexner Medical Center)

  • Theo G. M. Erp

    (University of California Irvine
    University of California Irvine, 309 Qureshey Research Lab)

  • Wei Cheng

    (Fudan University
    Ministry of Education
    Shanghai Medical College and Zhongshan Hospital Immunotherapy Technology Transfer Center
    Fudan University)

  • Jianfeng Feng

    (Fudan University
    Ministry of Education
    Zhejiang Normal University
    Fudan University)

Abstract

Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts from the ENIGMA, non-ENIGMA cohorts and public datasets. Using the Subtype and Stage Inference (SuStaIn) algorithm, we identify two distinct neurostructural subgroups by mapping the spatial and temporal ‘trajectory’ of gray matter change in schizophrenia. Subgroup 1 was characterized by an early cortical-predominant loss with enlarged striatum, whereas subgroup 2 displayed an early subcortical-predominant loss in the hippocampus, striatum and other subcortical regions. We confirmed the reproducibility of the two neurostructural subtypes across various sample sites, including Europe, North America and East Asia. This imaging-based taxonomy holds the potential to identify individuals with shared neurobiological attributes, thereby suggesting the viability of redefining existing disorder constructs based on biological factors.

Suggested Citation

  • Yuchao Jiang & Cheng Luo & Jijun Wang & Lena Palaniyappan & Xiao Chang & Shitong Xiang & Jie Zhang & Mingjun Duan & Huan Huang & Christian Gaser & Kiyotaka Nemoto & Kenichiro Miura & Ryota Hashimoto &, 2024. "Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50267-3
    DOI: 10.1038/s41467-024-50267-3
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