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Determinants of transthyretin levels and their association with adverse clinical outcomes among UK Biobank participants

Author

Listed:
  • Naman S. Shetty

    (Massachusetts General Hospital
    Harvard Medical School)

  • Mokshad Gaonkar

    (University of Alabama at Birmingham
    University of Alabama at Birmingham)

  • Nirav Patel

    (University of Alabama at Birmingham)

  • Akhil Pampana

    (University of Alabama at Birmingham)

  • Nehal Vekariya

    (University of Alabama at Birmingham)

  • Peng Li

    (University of Alabama at Birmingham)

  • Garima Arora

    (University of Alabama at Birmingham)

  • Pankaj Arora

    (University of Alabama at Birmingham
    Birmingham Veterans Affairs Medical Center)

Abstract

Transthyretin is a transport protein whose misfolding has been implicated in the development of cardiac amyloidosis. Here, we examine the clinical correlates of transthyretin levels, the differences in transthyretin levels according to the pathogenic V142I TTR variant carrier status, and the association of transthyretin levels with outcomes among 35,206 UK Biobank participants who underwent plasma profiling and were free from prevalent cardiovascular disease and chronic renal disease. Transthyretin levels are lower in females, decrease with increasing C-reactive protein levels, and increase with body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, albumin levels, triglyceride levels, and creatinine levels. V142I non-carriers [n = 35,167, mean: −0.1 (0.3)] have higher adjusted transthyretin levels compared with the carriers [n = 39, mean: −0.5 (0.3)] (p:

Suggested Citation

  • Naman S. Shetty & Mokshad Gaonkar & Nirav Patel & Akhil Pampana & Nehal Vekariya & Peng Li & Garima Arora & Pankaj Arora, 2024. "Determinants of transthyretin levels and their association with adverse clinical outcomes among UK Biobank participants," Nature Communications, Nature, vol. 15(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50231-1
    DOI: 10.1038/s41467-024-50231-1
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