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Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions

Author

Listed:
  • Angeliki Zarkali

    (UCL)

  • George E. C. Thomas

    (UCL)

  • Henrik Zetterberg

    (the Sahlgrenska Academy at the University of Gothenburg
    Sahlgrenska University Hospital
    Queen Square
    Clear Water Bay)

  • Rimona S. Weil

    (UCL
    UCL
    UCL)

Abstract

A major challenge in Parkinson’s disease is the variability in symptoms and rates of progression, underpinned by heterogeneity of pathological processes. Biomarkers are urgently needed for accurate diagnosis, patient stratification, monitoring disease progression and precise treatment. These were previously lacking, but recently, novel imaging and fluid biomarkers have been developed. Here, we consider new imaging approaches showing sensitivity to brain tissue composition, and examine novel fluid biomarkers showing specificity for pathological processes, including seed amplification assays and extracellular vesicles. We reflect on these biomarkers in the context of new biological staging systems, and on emerging techniques currently in development.

Suggested Citation

  • Angeliki Zarkali & George E. C. Thomas & Henrik Zetterberg & Rimona S. Weil, 2024. "Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49949-9
    DOI: 10.1038/s41467-024-49949-9
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    References listed on IDEAS

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    1. Erik Nutma & Nurun Fancy & Maria Weinert & Stergios Tsartsalis & Manuel C. Marzin & Robert C. J. Muirhead & Irene Falk & Marjolein Breur & Joy Bruin & David Hollaus & Robin Pieterman & Jasper Anink & , 2023. "Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    2. Miguel Ulla & Jean Marie Bonny & Lemlih Ouchchane & Isabelle Rieu & Beatrice Claise & Franck Durif, 2013. "Is R2* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-8, March.
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