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The maternal drug exposure birth cohort (DEBC) in China

Author

Listed:
  • Lu Li

    (Sichuan University
    Ministry of Education)

  • Ke Wang

    (Sichuan University
    Ministry of Education)

  • Meixian Wang

    (Sichuan University
    Ministry of Education)

  • Jing Tao

    (Sichuan University)

  • Xiaohong Li

    (Sichuan University)

  • Zhen Liu

    (Sichuan University)

  • Nana Li

    (Sichuan University)

  • Xiaoxia Qiu

    (The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region)

  • Hongwei Wei

    (The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region)

  • Yuan Lin

    (Fuzhou)

  • Yuan He

    (National Human Genetic Resource Center)

  • Ying Deng

    (Sichuan University)

  • Hong Kang

    (Sichuan University)

  • Yuting Li

    (Sichuan University)

  • Ping Yu

    (Sichuan University
    Ministry of Education)

  • Yanping Wang

    (Sichuan University
    Ministry of Education)

  • Jun Zhu

    (Sichuan University
    Ministry of Education)

  • Hanmin Liu

    (Ministry of Education
    Sichuan University)

Abstract

Drug exposure during pregnancy lacks global fetal safety data. The maternal drug exposure birth cohort (DEBC) study, a prospective longitudinal investigation, aims to explore the correlation of maternal drug exposure during pregnancy with pregnancy outcomes, and establish a human biospecimen biobank. Here we describe the process of establishing DEBC and show that the drug exposure rate in the first trimester of pregnant women in DEBC (n = 112,986) is 30.70%. Among the drugs used, dydrogesterone and progesterone have the highest exposure rates, which are 11.97% and 10.82%, respectively. The overall incidence of adverse pregnancy outcomes is 13.49%. Dydrogesterone exposure during the first trimester is correlated with higher incidences of stillbirth, preterm birth, low birth weight, and birth defects, along with a lower incidence of miscarriage/abortion. Due to the limitations of this cohort study, causative conclusions cannot be drawn. Further follow-up and in-depth data analysis are planned for future studies.

Suggested Citation

  • Lu Li & Ke Wang & Meixian Wang & Jing Tao & Xiaohong Li & Zhen Liu & Nana Li & Xiaoxia Qiu & Hongwei Wei & Yuan Lin & Yuan He & Ying Deng & Hong Kang & Yuting Li & Ping Yu & Yanping Wang & Jun Zhu & H, 2024. "The maternal drug exposure birth cohort (DEBC) in China," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49623-0
    DOI: 10.1038/s41467-024-49623-0
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