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Environmental and genetic regulation of Streptococcus pneumoniae galactose catabolic pathways

Author

Listed:
  • Banaz O. Kareem

    (University of Leicester
    University of Sulaimani)

  • Ozcan Gazioglu

    (University of Leicester)

  • Karina Mueller Brown

    (Carnegie Mellon University)

  • Medhanie Habtom

    (University of Leicester)

  • David G. Glanville

    (Loyola University Chicago)

  • Marco R. Oggioni

    (University of Leicester
    Department of Pharmacy and Biotechnology)

  • Peter W. Andrew

    (University of Leicester)

  • Andrew T. Ulijasz

    (Loyola University Chicago)

  • N. Luisa Hiller

    (Carnegie Mellon University)

  • Hasan Yesilkaya

    (University of Leicester)

Abstract

Efficient utilization of nutrients is crucial for microbial survival and virulence. The same nutrient may be utilized by multiple catabolic pathways, indicating that the physical and chemical environments for induction as well as their functional roles may differ. Here, we study the tagatose and Leloir pathways for galactose catabolism of the human pathogen Streptococcus pneumoniae. We show that galactose utilization potentiates pneumococcal virulence, the induction of galactose catabolic pathways is influenced differentially by the concentration of galactose and temperature, and sialic acid downregulates galactose catabolism. Furthermore, the genetic regulation and in vivo induction of each pathway differ, and both galactose catabolic pathways can be turned off with a galactose analogue in a substrate-specific manner, indicating that galactose catabolic pathways can be potential drug targets.

Suggested Citation

  • Banaz O. Kareem & Ozcan Gazioglu & Karina Mueller Brown & Medhanie Habtom & David G. Glanville & Marco R. Oggioni & Peter W. Andrew & Andrew T. Ulijasz & N. Luisa Hiller & Hasan Yesilkaya, 2024. "Environmental and genetic regulation of Streptococcus pneumoniae galactose catabolic pathways," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49619-w
    DOI: 10.1038/s41467-024-49619-w
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