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Light regulates nuclear detainment of intron-retained transcripts through COP1-spliceosome to modulate photomorphogenesis

Author

Listed:
  • Hua Zhou

    (Southern University of Science and Technology)

  • Haiyue Zeng

    (Shandong Laboratory of Advanced Agricultural Sciences at Weifang
    Peking University)

  • Tingting Yan

    (Southern University of Science and Technology)

  • Sunlu Chen

    (Nanjing Agricultural University)

  • Ying Fu

    (Shandong Laboratory of Advanced Agricultural Sciences at Weifang)

  • Guochen Qin

    (Shandong Laboratory of Advanced Agricultural Sciences at Weifang)

  • Xianhai Zhao

    (Southern University of Science and Technology)

  • Yueqin Heng

    (Southern University of Science and Technology)

  • Jian Li

    (Southern University of Science and Technology)

  • Fang Lin

    (Lanzhou University)

  • Dongqing Xu

    (Nanjing Agricultural University)

  • Ning Wei

    (Southwest University)

  • Xing Wang Deng

    (Southern University of Science and Technology
    Shandong Laboratory of Advanced Agricultural Sciences at Weifang
    Peking University)

Abstract

Intron retention (IR) is the most common alternative splicing event in Arabidopsis. An increasing number of studies have demonstrated the major role of IR in gene expression regulation. The impacts of IR on plant growth and development and response to environments remain underexplored. Here, we found that IR functions directly in gene expression regulation on a genome-wide scale through the detainment of intron-retained transcripts (IRTs) in the nucleus. Nuclear-retained IRTs can be kept away from translation through this mechanism. COP1-dependent light modulation of the IRTs of light signaling genes, such as PIF4, RVE1, and ABA3, contribute to seedling morphological development in response to changing light conditions. Furthermore, light-induced IR changes are under the control of the spliceosome, and in part through COP1-dependent ubiquitination and degradation of DCS1, a plant-specific spliceosomal component. Our data suggest that light regulates the activity of the spliceosome and the consequent IRT nucleus detainment to modulate photomorphogenesis through COP1.

Suggested Citation

  • Hua Zhou & Haiyue Zeng & Tingting Yan & Sunlu Chen & Ying Fu & Guochen Qin & Xianhai Zhao & Yueqin Heng & Jian Li & Fang Lin & Dongqing Xu & Ning Wei & Xing Wang Deng, 2024. "Light regulates nuclear detainment of intron-retained transcripts through COP1-spliceosome to modulate photomorphogenesis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49571-9
    DOI: 10.1038/s41467-024-49571-9
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    References listed on IDEAS

    as
    1. Sergey Bessonov & Maria Anokhina & Cindy L. Will & Henning Urlaub & Reinhard Lührmann, 2008. "Isolation of an active step I spliceosome and composition of its RNP core," Nature, Nature, vol. 452(7189), pages 846-850, April.
    2. Wojciech P. Galej & Chris Oubridge & Andrew J. Newman & Kiyoshi Nagai, 2013. "Crystal structure of Prp8 reveals active site cavity of the spliceosome," Nature, Nature, vol. 493(7434), pages 638-643, January.
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