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International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe

Author

Listed:
  • Mabel Budia-Silva

    (University of Freiburg – Medical Center)

  • Tomislav Kostyanev

    (University of Antwerp
    Technical University of Denmark)

  • Stefany Ayala-Montaño

    (University of Freiburg – Medical Center)

  • Jose Bravo-Ferrer Acosta

    (Universidad de Sevilla)

  • Maria Garcia-Castillo

    (Hospital Universitario Ramón y Cajal and Instituto Ramón y Caja de Investigación Sanitaria (IRYCIS)
    Institute de Salud Carlos III)

  • Rafael Cantón

    (Hospital Universitario Ramón y Cajal and Instituto Ramón y Caja de Investigación Sanitaria (IRYCIS)
    Institute de Salud Carlos III)

  • Herman Goossens

    (University of Antwerp)

  • Jesus Rodriguez-Baño

    (Universidad de Sevilla
    Institute de Salud Carlos III)

  • Hajo Grundmann

    (University of Freiburg – Medical Center)

  • Sandra Reuter

    (University of Freiburg – Medical Center)

Abstract

Carbapenem-resistant Klebsiella pneumoniae (CRKP) are of particular concern due to the spread of antibiotic resistance genes associated with mobile genetic elements. In this study, we collected 687 carbapenem-resistant strains recovered among clinical samples from 41 hospitals in nine Southern European countries (2016-2018). We identified 11 major clonal lineages, with most isolates belonging to the high-risk clones ST258/512, ST101, ST11, and ST307. blaKPC-like was the most prevalent carbapenemase-encoding gene (46%), with blaOXA-48 present in 39% of isolates. Through the combination and comparison of this EURECA collection with the previous EuSCAPE collection (2013-2014), we investigated the spread of high-risk clones circulating in Europe exhibiting regional differences. We particularly found blaKPC-like ST258/512 in Greece, Italy, and Spain, blaOXA-48 ST101 in Serbia and Romania, blaNDM ST11 in Greece, and blaOXA-48-like ST14 in Türkiye. Genomic surveillance across Europe thus provides crucial insights for local risk mapping and informs necessary adaptions for implementation of control strategies.

Suggested Citation

  • Mabel Budia-Silva & Tomislav Kostyanev & Stefany Ayala-Montaño & Jose Bravo-Ferrer Acosta & Maria Garcia-Castillo & Rafael Cantón & Herman Goossens & Jesus Rodriguez-Baño & Hajo Grundmann & Sandra Reu, 2024. "International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49349-z
    DOI: 10.1038/s41467-024-49349-z
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