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Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis

Author

Listed:
  • Julia Krämer

    (University Hospital Münster)

  • Carolin Balloff

    (Heinrich-Heine-University Düsseldorf
    Kliniken Maria Hilf)

  • Margit Weise

    (Heinrich-Heine-University Düsseldorf)

  • Valeria Koska

    (Heinrich-Heine-University Düsseldorf)

  • Yannik Uthmeier

    (Heinrich-Heine-University Düsseldorf)

  • Isabell Esderts

    (University Hospital Münster)

  • Mai Nguyen-Minh

    (University Hospital Münster)

  • Moritz Zimmerhof

    (University Hospital Münster)

  • Alex Hartmann

    (Hanseatic Statistics)

  • Michael Dietrich

    (Heinrich-Heine-University Düsseldorf)

  • Jens Ingwersen

    (Heinrich-Heine-University Düsseldorf)

  • John-Ih Lee

    (Heinrich-Heine-University Düsseldorf)

  • Joachim Havla

    (Ludwig-Maximilians University München)

  • Tania Kümpfel

    (Ludwig-Maximilians University München)

  • Martin Kerschensteiner

    (Ludwig-Maximilians University München
    Ludwig-Maximilians University München
    Munich Cluster for Systems Neurology (SyNergy))

  • Vivien Häußler

    (University Hospital Hamburg-Eppendorf
    University Medical Centre Hamburg-Eppendorf)

  • Christoph Heesen

    (University Hospital Hamburg-Eppendorf
    University Medical Centre Hamburg-Eppendorf)

  • Jan-Patrick Stellmann

    (University Hospital Hamburg-Eppendorf
    University Medical Centre Hamburg-Eppendorf
    UMR
    CEMEREM)

  • Hanna G. Zimmermann

    (corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Frederike C. Oertel

    (corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Marius Ringelstein

    (Heinrich-Heine-University Düsseldorf
    Heinrich-Heine-University Düsseldorf)

  • Alexander U. Brandt

    (corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Friedemann Paul

    (corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Orhan Aktas

    (Heinrich-Heine-University Düsseldorf)

  • Hans-Peter Hartung

    (Heinrich-Heine-University Düsseldorf
    University of Sydney
    Palacky University Olomouc)

  • Heinz Wiendl

    (University Hospital Münster)

  • Sven G. Meuth

    (Heinrich-Heine-University Düsseldorf)

  • Philipp Albrecht

    (Heinrich-Heine-University Düsseldorf
    Kliniken Maria Hilf)

Abstract

Retinal optical coherence tomography has been identified as biomarker for disease progression in relapsing-remitting multiple sclerosis (RRMS), while the dynamics of retinal atrophy in progressive MS are less clear. We investigated retinal layer thickness changes in RRMS, primary and secondary progressive MS (PPMS, SPMS), and their prognostic value for disease activity. Here, we analyzed 2651 OCT measurements of 195 RRMS, 87 SPMS, 125 PPMS patients, and 98 controls from five German MS centers after quality control. Peripapillary and macular retinal nerve fiber layer (pRNFL, mRNFL) thickness predicted future relapses in all MS and RRMS patients while mRNFL and ganglion cell-inner plexiform layer (GCIPL) thickness predicted future MRI activity in RRMS (mRNFL, GCIPL) and PPMS (GCIPL). mRNFL thickness predicted future disability progression in PPMS. However, thickness change rates were subject to considerable amounts of measurement variability. In conclusion, retinal degeneration, most pronounced of pRNFL and GCIPL, occurs in all subtypes. Using the current state of technology, longitudinal assessments of retinal thickness may not be suitable on a single patient level.

Suggested Citation

  • Julia Krämer & Carolin Balloff & Margit Weise & Valeria Koska & Yannik Uthmeier & Isabell Esderts & Mai Nguyen-Minh & Moritz Zimmerhof & Alex Hartmann & Michael Dietrich & Jens Ingwersen & John-Ih Lee, 2024. "Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49309-7
    DOI: 10.1038/s41467-024-49309-7
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