IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-48763-7.html
   My bibliography  Save this article

Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease

Author

Listed:
  • Samira Salihovic

    (Faculty of Medicine and Health, Örebro University)

  • Niklas Nyström

    (Uppsala University)

  • Charlotte Bache-Wiig Mathisen

    (Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo)

  • Robert Kruse

    (Faculty of Medicine and Health, Örebro University)

  • Christine Olbjørn

    (Akershus University Hospital)

  • Svend Andersen

    (Vestfold Hospital Trust)

  • Alexandra J. Noble

    (University of Oxford
    University of Oxford)

  • Maria Dorn-Rasmussen

    (Copenhagen University Hospital - Amager and Hvidovre
    Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre)

  • Igor Bazov

    (Faculty of Medicine and Health, Örebro University)

  • Gøri Perminow

    (Oslo University Hospital)

  • Randi Opheim

    (Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo)

  • Trond Espen Detlie

    (Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo)

  • Gert Huppertz-Hauss

    (Telemark Hospital Trust)

  • Charlotte R. H. Hedin

    (Department of Medicine Solna
    Dermatovenereology and Rheumatology)

  • Marie Carlson

    (Uppsala University)

  • Lena Öhman

    (Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg)

  • Maria K. Magnusson

    (Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg)

  • Åsa V. Keita

    (Linköping University)

  • Johan D. Söderholm

    (Linköping University)

  • Mauro D’Amato

    (Basque Foundation for Science
    CIC bioGUNE - BRTA
    LUM University)

  • Matej Orešič

    (Faculty of Medicine and Health, Örebro University
    University of Turku and Åbo Akademi University)

  • Vibeke Wewer

    (Copenhagen University Hospital - Amager and Hvidovre
    Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre)

  • Jack Satsangi

    (University of Oxford
    University of Oxford)

  • Carl Mårten Lindqvist

    (Faculty of Medicine and Health, Örebro University)

  • Johan Burisch

    (Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre
    Copenhagen University Hospital - Amager and Hvidovre)

  • Holm H. Uhlig

    (University of Oxford
    University of Oxford
    University of Oxford)

  • Dirk Repsilber

    (Faculty of Medicine and Health, Örebro University)

  • Tuulia Hyötyläinen

    (Örebro University)

  • Marte Lie Høivik

    (Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo)

  • Jonas Halfvarson

    (Faculty of Medicine and Health, Örebro University)

Abstract

Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.

Suggested Citation

  • Samira Salihovic & Niklas Nyström & Charlotte Bache-Wiig Mathisen & Robert Kruse & Christine Olbjørn & Svend Andersen & Alexandra J. Noble & Maria Dorn-Rasmussen & Igor Bazov & Gøri Perminow & Randi O, 2024. "Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48763-7
    DOI: 10.1038/s41467-024-48763-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-48763-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-48763-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48763-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.