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Dynamics of collagen oxidation and cross linking in regenerating and irreversibly infarcted myocardium

Author

Listed:
  • Eman A. Akam-Baxter

    (Harvard Medical School
    Massachusetts General Hospital)

  • David Bergemann

    (Harvard Medical School)

  • Sterling J. Ridley

    (Harvard Medical School)

  • Samantha To

    (Harvard Medical School)

  • Brittany Andrea

    (Harvard Medical School)

  • Brianna Moon

    (Harvard Medical School)

  • Hua Ma

    (Harvard Medical School)

  • Yirong Zhou

    (Harvard Medical School
    Harvard Medical School)

  • Aaron Aguirre

    (Harvard Medical School
    Harvard Medical School)

  • Peter Caravan

    (Massachusetts General Hospital
    Harvard Medical School)

  • Juan Manuel Gonzalez-Rosa

    (Harvard Medical School
    Boston College)

  • David E. Sosnovik

    (Harvard Medical School
    Massachusetts General Hospital
    Harvard Medical School)

Abstract

In mammalian hearts myocardial infarction produces a permanent collagen-rich scar. Conversely, in zebrafish a collagen-rich scar forms but is completely resorbed as the myocardium regenerates. The formation of cross-links in collagen hinders its degradation but cross-linking has not been well characterized in zebrafish hearts. Here, a library of fluorescent probes to quantify collagen oxidation, the first step in collagen cross-link (CCL) formation, was developed. Myocardial injury in mice or zebrafish resulted in similar dynamics of collagen oxidation in the myocardium in the first month after injury. However, during this time, mature CCLs such as pyridinoline and deoxypyridinoline developed in the murine infarcts but not in the zebrafish hearts. High levels of newly oxidized collagen were still seen in murine scars with mature CCLs. These data suggest that fibrogenesis remains dynamic, even in mature scars, and that the absence of mature CCLs in zebrafish hearts may facilitate their ability to regenerate.

Suggested Citation

  • Eman A. Akam-Baxter & David Bergemann & Sterling J. Ridley & Samantha To & Brittany Andrea & Brianna Moon & Hua Ma & Yirong Zhou & Aaron Aguirre & Peter Caravan & Juan Manuel Gonzalez-Rosa & David E. , 2024. "Dynamics of collagen oxidation and cross linking in regenerating and irreversibly infarcted myocardium," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48604-7
    DOI: 10.1038/s41467-024-48604-7
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